نتایج جستجو برای: glomerular permeability
تعداد نتایج: 78068 فیلتر نتایج به سال:
Glomerular podocytes are highly specialized cells with a complex cytoarchitecture. Their most prominent features are interdigitated foot processes with filtration slits in between. These are bridged by the slit diaphragm, which plays a major role in establishing the selective permeability of the glomerular filtration barrier. Injury to podocytes leads to proteinuria, a hallmark of most glomerul...
BACKGROUND/AIMS Glomerular endothelium dysfunction leads to the progression of renal architectonic and functional abnormalities in early-stage diabetic nephropathy (DN). Advanced glycation end products (AGEs) and receptor for AGEs (RAGE) are proved to play important roles in diabetic nephropathy. This study investigated the role of Salvianolic acid A (SalA) on early-stage DN and its possible un...
The functional role of glomerular parietal epithelial cells (PECs) remains poorly understood. To test the hypothesis that PECs form an impermeable barrier to filtered protein through the formation of tight junctions (TJ), studies were performed in normal animals and in the anti-glomerular basement membrane (GBM) model of crescentic nephritis. Electron microscopy showed well-defined TJ between P...
The podocyte is a specialized epithelial cell with numerous interdigitating foot processes which play an important role in the regulation of the glomerular basement membrane (GBM) permeability. The nephrotic syndrome results from increased glomerular permeability to proteins and is structurally belived to be associated with podocyte foot process effacement. Despite increasing knowledge of the m...
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