BACKGROUND The present study aimed to evaluate the effect of methotrexate (MTX) alone and in combination with meglumine antimoniate (MA, Glucantime) against sensitive and MA-resistant Leishmania tropica stages in vitro. METHODS The present study was carried out in 2014 in Leishmaniasis Research Center at School of Medicine, Kerman University of Medical sciences, Kerman, Iran. The effects of M...

OBJECTIVE To explore the knowledge, beliefs, and practices (KBPs) regarding cutaneous leishmaniasis (CL) treatment held by an endemic population in Ecuador. METHODS A follow-up to research done several years before, this study used random cluster sampling to select 529 adults who lived in rural northwestern Ecuador. Data were collected over a 24-month period using in-depth interviews suppleme...

Pentavalent antimonials are still the first drug of choice for the treatment of cutaneous leishmaniasis (CL). Like other treatments, they can cause adverse reactions including musculoskeletal pain, gastrointestinal disturbances, and mild to moderate headaches. In this paper, we report the first case of an infant who developed acute urticaria after her mother's parenteral use of meglumine antimo...

Background: According to the drug resistance and side effects of the standard treatments for leishmaniasis, achieving effective treatment with less side effects and more benefits is of paramount importance. The present study aimed to evaluate the effect of Aloe vera leaf exudate on Leishmania major under in vitro and in vivo models, in inbred BALB/c mice. Methods: Different concentrations of bo...

Background: Several treatment modalities have been used for cutaneous leishmaniasis (CL) with various results. In vitro and in vivo studies have shown inhibitory effects of zinc sulfate (ZnSO4) on Leishmania parasites. Objective: To compare the efficacy of intralesional injections of 2% ZnSO4 solution with meglumine antimonate (Glucantime) in the treatment of acute Old World CL. Patients ...

introduction: this study was done to compare the efficacy of interlesional injection of glucantime method and cryotherapy with interlesional injection in treatment of cutaneous leishmaniasis in qom province. methods: in this randomized controlled trial patients were randomly allocated in the two arms of the study:one receiving interalesional glucantime injection weekly and the other receiving b...

background: leishmaniasis is a complex disease which presents as visceral, cutaneous and mucocutaneous forms. the current treatment options for this infection are very limited and the immunological state of the host appears to play an important role in the efficacy of the treatment. immunostimulation through immune response activating agents such as imiquimod is another rational approach for th...

background: to evaluate immunotherapy against canine visceral leishmaniasis, leishmania ma­jor antigen and heat-killed mycobacterium vaccae (srl172) were used as stimulators of immune de­fense mechanisms and the results were compared with standard chemotherapy meglumine antimoni­ate. methods: nineteen mongrel dogs aging 1-3 years old were used in this experiment. infection was carried out in 15...