Glucose-6-phosphate dehydrogenase (G6PD) deficiency is common in tropical Sub-Saharan countries. The allele most frequently associated with G6PD deficiency in this a region is G6PD 376G/202A. Here, we show that, the prevalence of G6PD deficiency is 12% in the Sereer ethnic group from Senegal ant that the 376G/968C genotype is predominant; the frequency of the 376G/202A genotype is very low in t...

INTRODUCTION Glucose-6-phosphate dehydrogenase deficiency is an X-linked recessive disease that causes acute or chronic hemolytic anemia and potentially leads to severe jaundice in response to oxidative agents. This deficiency is the most common human innate error of metabolism, affecting more than 400 million people worldwide. CASE PRESENTATION Here, we present the first documented case of k...

Red blood cells carry oxygen in the body and Glucose-6-Phosphate Dehydrogenase protects these cells from oxidative chemicals. If there is a lack of Glucose-6-Phosphate Dehydrogenase, red blood cells can go acute hemolysis. Convulsion is a rare presentation for acute hemolysis due to Glucose-6-Phosphate Dehydrogenase deficiency. Herein, we report a case report of a Glucose-6-Phosphate Dehydrogen...

Modification of the endocrine milieu intérieur by administration or withdrawal of hormones considerably influenced the concentration in liver of lactic dehydrogenase, glucose-6-phosphate dehydrogenase, and 6-phosphogluconic dehydrogenase. Hormones effective in this regard are thyroxine, estradiol-17beta, dihydrotestosterone, and 3alpha-hydroxysteroids in the androstane series. These hormonal ef...

O VER THE PAST DECADE there has been an increasing sense of confusion concerning the significance of the gradually escalating number of putative glucose-6phosphate dehydrogenase (G-6-PD) variants. Our ability to sequence G-6-PD at the DNA level is rapidly changing our perception of what is alike and what is different about these variants. What has seemed to be alike now turns out to be differen...

Glucose-6-phosphate dehydrogenase (G6PD) from Leuconostoc mesenteroides is one of a small number of dehydrogenases that can utilize either NAD or NADP. The physiological roles of these two coenzymes are quite different and the enzymes that utilize them are generally specific for one or the other coenzyme. An essential function of G6PDs in animals, for example, is to generate NADPH for reductive...

In addition to the Neurospora crassa mutant col-2, mutations in two other unlinked genes, balloon and frost, lead to distinct morphological growth and abnormal glucose-6-phosphate dehydrogenases. The glucose-6-phosphate dehydrogenases from these strains have increased thermolabilities, altered kinetic parameters, and distinctive electrofocusing patterns. The altered enzyme segregates with each ...

Human erythrocyte glucose 6-phosphate dehydrogenase (o-glucose 6-phosphate :nicotinamide adenine dinucleotide phosphate oxidoreductase, EC 1.1.1.49) was purified by column chromatography with diethylaminoethyl cellulose, calcium phosphate gel, carboxymethyl cellulose, diethylaminoethyl Sephadex, and carboxymethyl Sephadex. A homogeneous preparation was obtained in over-all yield of about 50%. T...

In glucose-6-phosphate-dehydrogenase deficiency (favism), exposure to oxidant agents can trigger hemolytic crises. The intravenous administration of very high doses vitamin C was proposed as a treatment for severe coronavirus disease 2019 (COVID-19) pneumonia. Unlike low doses, (>6 gr daily) promote H2O2 formation, oxidation hemoglobin methemoglobin and, eventually, anemia in patients with f...