Su, JUDY Y., AND WILLIAM F. FRIEDMAN. Comparison of the responses of fetal and adult cardiac muscle to hypoxia. Am. J. Physiol. 224(6): 1249-1253. 1973.-The responses of cardiac tissue isolated from fetal and adult sheep were compared after selective inhibition of aerobic and anaerobic metabolism. The frequency of contraction of adult right atria was significantly more depressed by oxygen depri...

Ghrelin, a hormone whose levels increase during food deprivation, plays a pivotal role in the regulation of food intake, energy metabolism and storage, as well as in insulin sensitivity. Here, we investigated the effects of acyl-ghrelin neutralization with the acyl-ghrelin-binding compound NOX-B11(2) during the fasting-refeeding cycle. Our data demonstrate that ghrelin neutralization with NOX-B...

Depriving cultured cells of glucose increases glucose-regulated protein synthesis, suppresses heat shock protein synthesis, and increases sensitivity to killing by hyperthermia. The present study shows that supplementation of glucose-free culture medium with uridine or a number of other nucleosides reverses all these effects of glucose deprivation. Uridine is more effective in this regard than ...

Tolerance of glucose deprivation is an important factor for cancer proliferation, survival, migration and progression. To systematically understand adaptive responses under glucose starvation in cancers, we analyzed reverse phase protein array (RPPA) data of 115 protein antibodies across a panel of approximately 170 heterogeneous cancer cell lines, cultured under normal and low glucose conditio...

Objective: This study was planned to investigate whetherCoriandrum sativum (C. sativum) is capable of protecting neurons against glucose/serum deprivation (GSD)-induced cytotoxicity. Material and Methods: The PC12 cells were cultivated for 24 h in standard media (high-glucose DMEM containing Fetal Bovine Serum) or for 6 h in GSD condition (glucose-free DMEM, without serum) in the absence or pr...

The signaling pathways that govern survival response in hepatic cancer cells subjected to nutritional restriction have not been clarified yet. In this study we showed that liver cancer cells undergoing glucose deprivation both arrested in G0/G1 and died mainly by apoptosis. Treatment with the AMPK activator AICAR phenocopied the effect of glucose deprivation on cell survival, whereas AMPK silen...

Balancing the acquisition, allocation and storage of energy during periods of food deprivation is critical for survival. We show that natural variation in the foraging (for) gene, which encodes a cGMP-dependent protein kinase (PKG) in the fruit fly Drosophila melanogaster, affects behavioral and physiological responses to short-term food deprivation. Rover and sitter, natural allelic variants o...