1. Glutathione redox cycle alterations induced by acute treatment of nickel, cadmium and copper, have been investigated in liver and kidney of adult male rats. 2. In liver, nickel treatment decreased GSH and GSSG levels, followed by a significant rebound in GSH content. Copper produced drastic reduction in the GSH/GSSG ratio, while cadmium treatment altered GSSG concentrations. 3. In kidney, th...

BACKGROUND Glutathione is considered essential for survival in mammalian cells and yeast but not in prokaryotic cells. The presence of a nuclear pool of glutathione has been demonstrated but its role in cellular proliferation and differentiation is still a matter of debate. PRINCIPAL FINDINGS We have studied proliferation of 3T3 fibroblasts for a period of 5 days. Cells were treated with two ...

Abstract Plant growth regulators melatonin (MT) and salicylic acid (SA) have potent roles in plant salt tolerance. However, only a few reports studied the influence of their combined treatment on The current study, as first investigation, was aimed to evaluate effect MT SA antioxidant glyoxalase defense machineries salt-stressed wheat plants. In present potential role 70 μM and/or 75 mg l −1 mi...

The antioxidant capacity of the glutathione redox cycle and the concentrations of selenium in serum, red blood cells or whole blood, and polymorphonuclear leucocytes was evaluated in nine patients with severe rheumatoid arthritis (RA) and eight healthy controls receiving daily supplementation with 250 micrograms selenomethionine for six months. Serum and whole blood concentrations of selenium a...

Meister, 1979~) . In kidney and probably at other sites of high pglutamyl transpeptidase concentration, intracellular glutathione is transported to the membrane-bound enzyme; the products of enzyme action (y-glutamyl amino acids, cysteinylglycine) are taken up by the cell. Tissues such as muscle and liver, which have low activities of transpeptidase, transport glutathione to the blood plasma. G...

Bangia fuscopurpurea is a widespread intertidal seaweed that commercially cultured in China. This frequently exposed to hyposalinity stress, but little known about the adaptation mechanisms. Ascorbate−glutathione (AsA−GSH) cycle plays important roles many organisms under variety of abiotic including hyposaline stress. In this study, we investigated response key metabolites and enzymes involved ...

Human blood monocytes and neutrophils were incubated with an H202-generating system (glucose plus glucose oxidase) in the presence and absence of 2 mM sodium azide. to assess the importance of catalase in the protection of these cells against heavy external oxidative stress (50 nmole H202/mI/min). Before and after these incubations. the cell integrity was determined. as well as the following ce...