results theophylline-treated rats showed mda level elevation and gpx activity reduction. quercetin treatment improved heart conditions and resulted in a significant reduction in mda levels and elevation in gpx activity. moreover, co-administration of quercetin and theophylline increased the heart weight significantly. furthermore, histophatological study showed no changes in the treated groups....

Abstract Reactive oxygen species (ROS) have long been known to contribute the development and severity of Inflammatory Bowel Disease. However, more recent data indicates ROS may not always be pathogenic, in fact necessary for intestinal homeostasis. Thus, role intestine, antioxidant proteins which regulate ROS, contextual dose-dependent. Members glutathione peroxidase (GPx) family are antioxida...

Osteoporosis is a multifactorial skeletal pathology with a main genetic component. To date, however, the majority of genes associated with this pathology remain unknown since genes cataloged to date only explain a part of the heritability of bone phenotypes. In the present study, we have used a genome-wide gene expression approach by means of microarrays to identify new candidate genes involved...

Two enzymatic mechanisms have been proposed for the metabolism of hydroperoxy-phospholipids: i) the combined action of phospholipase A2 and glutathione peroxidase, and/or ii) direct enzymatic reduction. The latter reaction may be catalyzed by selenium-dependent phospholipid hydroperoxide glutathione peroxidase and/or by glutathione S-transferase alpha. To study the pathway of this reaction, we ...

The influence of histamine and quercetin, as well their combined effect on the content in whole blood, superoxide anion radical, sialic acids, sulfhydryl groups, activity catalase, glutathione peroxidase, transferase rat erythrocytes was studied. It established that quercetin at a concentration 0.1 mM causes an increase blood rats, while all other studied concentrations cause significant decrea...

Thiacremonone (2, 4-dihydroxy-2, 5-dimethyl-thiophene-3-one) is an antioxidant substance as a novel sulfur compound generated from High-Temperature-High-Pressure-treated garlic. Peroxiredoxin 6 (PRDX6) is a member of peroxidases, and has glutathione peroxidase and calcium-independent phospholipase A2 (iPLA2) activities. Several studies have demonstrated that PRDX6 stimulates lung cancer cell gr...

Serum C-reactive protein (CRP) elevation predicts the development of heart failure in patients with hypertension. CRP activates macrophages and enhances oxidative stress. We hypothesize that CRP itself has a pathogenic role in the development of pressure overload-induced cardiac remodeling. Transgenic mice with human CRP overexpression (CRPtg) and nontransgenic littermates (CON) were subjected ...

conclusions se supplementation can increase plasma se concentration and rbc gsh-pxs activity in patients with different stages of ckd. background plasma selenium (se) concentration and glutathione peroxidase (gsh-pxs) enzyme activity of the patients with chronic kidney disease (ckd) are usually lower than healthy individuals; however, the effect of se supplementation on the gsh-pxs activity in ...

Twenty-one pregnant women living in Xichang County, China, a selenium-deficient area, were divided into two groups and given either a placebo (n = 10) as yeast or selenium-enriched yeast tablets (n = 11) to provide 100 microg selenium per day. This supplementation was begun the last trimester of pregnancy and continued for 3 months after parturition. Plasma selenium levels and glutathione perox...