objective(s): buthionine sulfoximine (bso) inhibits synthesis of glutathione as the main intracellular antioxidant. the aim of the present study is to investigate the effect of bso-induced oxidative stress on histological structure of testis, testosterone secretion and semen parameters. materials and methods: thirty male balb/c mice were divided into 3 groups. in control group, the mice did not...

objective(s):to evaluate the effect of graptophyllum pictum on lipid peroxidation and tissue antioxidant enzymes in liver and kidney of gentamicin induced nephrotoxic rats. materials and methods: animals were grouped into 6: group 1 received gum acacia, group 2 received g. pictum ethanol extract (300 mg/kg), group 3 received gentamicin, groups 4, 5, 6 received gentamicin along with g. pictum at...

glutathione transferases are multifunctional proteins involved in several diverse intracellular events such as primary and secondary metabolisms, signaling and stress metabolism. these enzymes have been subdivided into eight classes in plants. the phi class, being plant specific, is the most represented. in the present study, based on the sequences available at genbank, different primers were d...

glutathione transferase (gst) is a family of multifunctional detoxification enzymes which are mainly cytosolic that detoxify natural and exogenous toxic compounds through conjugation with glutathione tripeptide. its conjugates can be transported to vacuoles or apoplast. these conjugates are generally less toxic than the parent compounds. glutathione transferase is identified and isolated from m...

results the level of gsh significantly decreased. in contrast, the plasma level of mda significantly increased in a dose dependent manner in crvi-treated rats, when compared to control animals. simv had no effect on the biochemical parameters when compared to control rats, but significantly increased gsh concentration and decreased mda level in crvi-treated rats. materials and methods sixty-fou...

glutathione s-transferases (gsts) are encoded by a superfamily of genes and play a role in the detoxification of potential carcinogens. the human gsts are divided into four classes: alpha, mu, pi and theta. previous studies indicated that the absence of the glutathione s-transferase m1 (gstm1) protein correlated with an increased risk of developing some types of cancers. association between spe...

background: dzn (diazinon) is an organophosphate insecticide that had been used in agriculture and for domestic and veterinary use for several years and caused many negative effects on plants and animal species, especially on human. the aim of present study was to evaluate the effects of dzn on mda (malondialdehyde) and gsh (glutathione) levels in female rat reproductive tissue (ovary) and to a...

background: in fertile women, glycodelin and glutathione peroxidase 3 (gpx3) genes expression rises during the luteal phase, with a peak occurring during the implantation window. the expression of these genes decreases in women with myomas. to determine whether myomectomy would reverse glycodelin and gpx3 expression, we evaluated the transcript levels of these genes in the endometrium of patien...