Radical alkylation of 2-(tert-butyl)-2-methyldioxolan-4-one, a chiral equivalent of glycolic acid, occurs with good to high diastereoselectivity that compares favorably with the corresponding enolate alkylation. The importance of the position of the transition state position, early or late, is highlighted.

The grim prognosis for patients diagnosed with malignant gliomas necessitates the development of new therapeutic strategies for localized and sustained drug delivery to combat tumor drug resistance and regrowth. Here we introduce drug encapsulated aerosolized microspheres as a biodegradable, intelligent glioma therapy (DREAM BIG therapy). DREAM BIG therapy is envisioned to deliver three chemoth...

The oxidation of acetic, glycolic, glyoxylic, oxalic and formic acid has been studied on boron doped diamond electrodes. Our voltammetry study rotating disk electrodes highlights clear differences between the carboxylic acids (formic, oxalic, glyoxylic glycolic acid) that can be oxidized via a direct electron transfer (DET) acetic which presumably solely by •OH radicals formed in region where w...

BACKGROUND: Acanthosis nigricans is a common dermatological disorder characterized by hyperpigmented and hyperkeratotic velvety skin lesions. It can be manifestation of systemic disease. OBJECTIVE: This study aims to evaluate the clinical laboratory predictive factors in treatment pseudo-acanthosis nigricans. PATIENTS AND METHODS: included 20 patients with from outpatient clinic. All cases were...