Background: Evidence suggests that children are more susceptible to radiation risks or hazards. In particular, their gonads are more sensitive to the effects of radiation, especially at or below reproductive age. Protecting the gonads of children and adults is of particular importance to the imaging. Aim: To investigate level of the use of gonad protection during paediatric abdomen and pelvic X...

The zinc finger transcription factor Gata4, is associated with gonadal development in many species. The present study characterizes temporal and spatial localization of Gata4 throughout gonadogenesis in porcine embryos. Immunohistochemical studies illustrated that Gata4 protein is present in the coelomic epithelium prior to histological differentiation of the nascent bipotential gonad, marking ...

BACKGROUND Our knowledge on zebrafish reproduction is very limited. We generated a gonad-derived cDNA microarray from zebrafish and used it to analyze large-scale gene expression profiles in adult gonads and other organs. METHODOLOGY/PRINCIPAL FINDINGS We have identified 116638 gonad-derived zebrafish expressed sequence tags (ESTs), 21% of which were isolated in our lab. Following in silico n...

Background: Celery (Apium graveolens) has many therapeutic effects.This plant has many phytoestrogens that can affect on the reproductive endocrine system and can reduce fertility .In this study, hydro alcoholic extracts of celery leaves on the pituitary-gonad axis in young male l mice of Balb/C was investigated. Materials and Methods: The samples were randomly divided into 5 groups (three trea...

The direction of gonadal development is established through the predominance of one of two sex-determining pathways in bipotential gonads. When Sry is expressed, the male pathway prevails and a series of prominent changes in morphology and function of the gonad lead to testis differentiation. In the absence of Sry, the female pathway gains control of gonadal development, resulting in a lack of ...

The aim of the present study was to evaluate sex differences in tumorigenesis by assessing the number of Ki-67-positive cells [Ki-67(+)] in urethane-induced mice lung tumors and the effect of sodium valproate (NaVP) in BALB/c mice. Gonad-intact and gonadectomized female and male mice were divided into the following groups: i) Treated with urethane, ii) treated with urethane and NaVP and iii) go...