We reported a case of a 17 year-old female, who presented with primary amenorrhea. She had normal female external genitalia and a 46,XY karyotype. Hormone profiles and laparoscopic findings confirmed a diagnosis of 46,XY gonadal dysgenesis (Swyer syndrome). Prophylactic gonadectomy was performed laparoscopically to prevent the risk of malignant germ cell tumor. Current management of this rare s...

The effects of gonadectomy on amphetamine-induced rotational behavior were studied in male and female rats. Different systemic doses were used to produce equivalent brain concentrations of the drug in each group, thereby controlling for sex differences in the metabolism of amphetamine. Ovariectomy of female rats significantly attenuated amphetamine-induced rotation, whereas castration of males ...

Alimentary hypercholesterolemia acting over a sufficient period of time (in rabbits with all organs intact, 110 days or longer) causes deposition of cholesterol within the intima of the aorta. Deposition of cholesterol within the intima of the aorta initiates the formation of experimental atheromata. Thyroidectomy, splenectomy, and gonadectomy augment hypercholesterolemia and thereby facilitate...

introduction: complete androgen insensitivity syndrome (previously called testicular feminization) is specified by a 46 xy karyotype and negative sex chromatin, bilateral undescended testes, female genitalia appearance, and lack of mullerian derivatives. discussion: our medline search revealed that this is the first reported case of bilateral sertoli–leydig cell tumor (slct) in androgen insensi...