ObjectiveTo report a successful case of ovarian hyperstimulation and oocyte cryopreservation in transgender male adolescent after suppression with gonadotropin-releasing hormone (GnRH) agonist while using the aromatase inhibitor letrozole to maintain low serum estradiol.DesignCase report.SettingDivision Reproductive Endocrinology Infertility, Washington University St. Louis School Medicine, St ...

objective: to evaluate the impact of luteal phase support with vaginal progesterone on pregnancy rates in the intrauterine insemination (iui) cycles, stimulated with clomiphene citrate and human menopausal gonadotropin (hmg), in sub fertile couples. materials and methods: this prospective, randomized, double blind study was performed in a tertiary infertility center from march 2011 to january 2...

background: this research investigated the response of vascular active factors, vascular endothelial growth factor (vegf) and angiotensin-ii (at-ii) to ovarian stimulation during 24 hours in patients with polycystic ovary syndrome (pcos). materials and methods: in this clinical trial study, 52 patients with pcos and 8 control cases were stimulated with human chorionic gonadotropin (hcg) on the ...

This study investigated the participation of MAPK in the resumption of meiosis [germinal vesicle breakdown (GVB)] in oocytes and cumulus expansion using oocyte-cumulus cell complexes (OCC) from Mos-null mice (Mos(tm1Ev)/Mos(tm1Ev), hereafter Mos(-/-)). MAPK activity was not detected in Mos(-/-) oocytes whether they matured in vivo or in vitro, with or without gonadotropin stimulation. Therefore...

Various serine proteases (e.g., trypsin, alpha-chymotrypsin, Pronase, and subtilisin) stimulate adenylate cyclase [ATP pyrophosphate-lyase (cyclizing), EC 4.6.1.1] activity in a membrane-enriched fraction of the rat ovary. Maximum stimulation is observed at protease concentrations ranging from 3 to 10 mug/ml. Higher protease concentrations inhibit ovarian adenylate cyclase in a dose-dependent m...

Cancer is not uncommon and no longer considered to be an incurable disorder. 10% of cancer cases occur under the age of 45. There is a remarkable improvement in treatment and survival rates. Today women have been delaying initiation of childbearing because the incidence of most cancers increases with age. Delayed childbearing results in more female cancer survivors. As a consequence there is an...