A new type of interaction in which fruit juices diminish oral drug bioavailability through inhibition of uptake transport is the focus of this review. The discovery was based on an opposite to anticipated finding when assessing the possibility of grapefruit juice increasing oral fexofenadine bioavailability in humans through inhibition of intestinal MDR1-mediated efflux transport. In follow-up ...

The biology of the citrus psyllid Diaphorina citri Kuwayama was studied at 25 degrees C on four commonly grown citrus and related plants [rough lemon, Citrus jambhiri Lush; sour orange, C aurantium L.; grapefruit, C. paradisi Macfadyen; and orange jessamine, Murraya paniculata (L.) Jack] in the laboratory. The biological characteristics of each life stage are described. The average egg incubati...

The present study was aimed to assess the efficacy of individual and combined effects novel fuller earth, rock phosphate, biochar (grapefruit peel) at 1% dosage on maize plant growth, soil chemical properties anduptake toxic metals (TMs), such as Cu, Zn, Fe, Cd, by sown in Korangi (district Karachi, Pakistan) heavily polluted less (K-HP K-LP) soils. obtained results indicate that dry biomass cr...

Jeruk Bali (Citrus maxima) yang termasuk keluarga Rutaceae merupakan tanaman berasal dari Indonesia. Tanaman ini memiliki banyak fungsi terutama pada bagian kulit jeruk dimana terdapat kandungan pektin digunakan sebagai aktivitas antibakteri. Kebaruan penelitian karena meneliti tentang antibakteri ekstrak maxima pericarpium) terhadap bakteri Pseudomonas aeruginosa dan Enterococcus faecalis. Tuj...

Sexually mature, mated female Mexican fruit ßies, Anastrepha ludens (Loew), from a laboratory culture, whether starved or not, were attracted to grapefruit in a wind tunnel. Females starved for 24 h were more strongly attracted than fed females but those starved for 48 h were equivalent to fed females in responsiveness. There were no signiÞcant differences in propensity to attempt oviposition o...

1 Identify the mechanism of grapefruit juice-drug interactions and drugs involved with significant grapefruit-drug interactions. 2 Describe potential effects of grapefruit juice-drug interactions.. 3 Discuss medications that may be affected and degree of risk associated with common interacting medications.. 4 Identify effective alternative medications that do not interact (for patients who do n...

Because grapefruit contains fibre, vitamin C, antioxidants and phytochemicals, the fruit and its juice are consumed widely to help meet daily nutritional requirements. However, in the past 15 years, studies have shown that grapefruit juice can induce a several-fold increase in the plasma levels of particular drugs that can result in increased therapeutic or even toxic effects. The effect seems ...

BACKGROUND The aim of the study was to verify that the concomitant presence of grapefruit flavonoid extract with inulin in a Western-type diet may provide synergistic effects to the hindgut metabolism, as well as blood lipid and mineral profiles. METHODS Forty male Wistar rats were distributed into 4 groups and fed for 28 days with diets rich in fat, cholesterol and protein. A two-way repeate...