نتایج جستجو برای: grn reverse engineering models
تعداد نتایج: 1233163 فیلتر نتایج به سال:
Objective To quantify the effect of genetic factors and generations influencing the age at onset (AAO) in families with frontotemporal lobar dementia (FTD) due to C9ORF72 hexanucleotide repeat expansions and GRN mutations. Methods We studied 504 affected individuals from 133 families with C9ORF72 repeat expansions and 90 FTD families with mutations in GRN, 2 major genes responsible for FTD an...
brain injury is a complex event leading to tissue damage and functional deficits by primary and secondary mechanisms. since the application of tissue engineering approaches is a new topic in the treatment of brain injury, producing a proper experimental model to evaluate the effects of tissue engineering products on damaged brain tissue is required. in the present study, a simple and reproducib...
The activity of a biological cell is regulated by interactions between genes and proteins. In artificial intelligence, this has led to the creation of developmental gene regulatory network (GRN) models which aim to exploit these mechanisms to algorithmically build complex designs. The emerging field of GRNs for control aims to instead exploit these natural mechanisms and this ability to encode ...
In this position paper, we advocate the automated reverse-engineering of UML v2.0 dynamic models, i.e., sequence diagrams and statecharts, to perform highlevel analyses, such as conformance checking and pattern identification. Several approaches exist to reverseengineer UML dynamic models; However, to our best knowledge, none of these approaches consider reverseengineering UML v2.0 dynamic mode...
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This paper provides the basic information about Reverse Software Engineering and its advantages and disadvantages of Reverse Engineering. Today Reverse Engineering is used in many fields of Information Technology in form of Legacy compatibility, Malware Analysis, Network Analysis, Binary code patching, debugging, and improvising existing algorithms, rapid prototyping and even software reusabili...
Software systems have become business-critical for many companies. These systems are usually large and complex. Some have evolved over decades and therefore are known as legacy systems. These legacy systems need to be maintained and evolved due to many factors, including error correction, requirements change, business rules change, structural re-organization, etc. A fundamental problem in maint...
Engineering is many times described as making practical application of the knowledge of pure sciences in the solution of a problem or the application of scientific and mathematical principles to develop economical solutions to technical problems, creating products, facilities, and structures that are useful to people. What if the opposite occurs? There is some product that may be a solution to ...
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