The Drosophila ovary is an excellent system with which to study germline stem cell (GSC) biology. Two or three female GSCs are maintained in a structure called a niche at the anterior tip of the ovary. The somatic niche cells surrounding the GSCs include terminal filament cells, cap cells and escort stem cells. Mounting evidence has demonstrated that BMP-like morphogens are the immediate upstre...

In this paper we establish a generalized noise reduction scheme, called the Spatially Pre-processed Speech Distortion Weighted Multi-channel Wiener filter (SP-SDW-MWF), that encompasses the Generalized Sidelobe Canceller (GSC) and a recently developed Multi-channel Wiener Filtering (MWF) technique as extreme cases and allows for in-between solutions. Compared to the widely studied GSC with Quad...

In this paper, we discuss a new generalization of univariate skew-Cauchy distribution with two parameters, we denoted this by GSC(&lambda1, &lambda2), that it has more flexible than the skew-Cauchy distribution (denoted by SC(&lambda)), introduced by Behboodian et al. (2006). Furthermore, we establish some useful properties of this distribution and by two numerical example, show that GSC(&lambd...

BACKGROUND The aim of this study was to evaluate the diagnostic value of the asphericity (ASP) as a novel quantitative parameter, reflecting the spatial heterogeneity of tracer uptake, in the staging process of patients with 68Ga-PSMA-HBED-CC positron emission tomography (PET)-positive prostate cancer (PC). In this study, 37 patients (median age 72 years, range 52-82 years) with newly diagnosed...

Trustworthy corpora are necessary for training and meaningful evaluation of algorithms which use annotations. These standard collections are called Gold Standard Corpora (GSC). However the construction of GSC is a laborious and time-consuming process and size, quality and most of all availability of task-specific GSC directly influence the development of machine learning based natural language ...

In the Drosophila oogenesis, germline stem cells (GSCs) continuously self-renew and differentiate into daughter cells for consecutive germline lineage commitment. This developmental process has become an in vivo working platform for studying adult stem cell fate regulation. An increasing number of studies have shown that while concerted actions of extrinsic signals from the niche and intrinsic ...

Reactive oxygen species (ROS) are byproducts generated during normal cellular metabolism, and redox states have been shown to influence stem cell self-renewal and lineage commitment across phyla. However, the downstream effectors of ROS signaling that control stem cell behavior remain largely unexplored. Here, we used the Drosophila testis as an in vivo model to identify ROS-induced effectors t...

The clinicopathological heterogeneity of glioblastoma (GBM) and the various genetic and phenotypic subtypes in GBM stem cells (GSCs) are well described. However, the relationship between GSCs and the corresponding primary tumor from which they were isolated is poorly understood. We have established GSC-enriched neurosphere cultures from 15 newly diagnosed GBM specimens and examined the relation...

Glioblastoma multiforme (GBM) is the most common and aggressive brain tumor with limited therapeutic options. Glioma stem cell (GSC) is thought to be greatly responsible for glioma tumor progression and drug resistance. But the molecular mechanisms of GSC deriving recurrence and drug resistance are still unclear. SOX9 (sex-determining region Y (SRY)-box9 protein), a transcription factor express...

Ion channels and transporters have increasingly recognized roles in cancer progression through the regulation of cell proliferation, migration, and death. Glioblastoma stem-like cells (GSCs) are a source of tumor formation and recurrence in glioblastoma multiforme, a highly aggressive brain cancer, suggesting that ion channel expression may be perturbed in this population. However, little is kn...