Shoulder injury (including isolated gleno-humeral dislocation, fracture dislocation or fracture without evidence of dislocation) is a rare complication of seizures occurring with or without direct trauma. Bilateral posterior fracture dislocation may occur as a direct consequence of the motor manifestations of generalized tonic–clonic seizures (GTCS) in the absence of trauma. Although described ...

Background: Recently, there has been much more interest in the use of medicinal plants in search of novel therapies for human neurodegenerative diseases such as epilepsy. In the present study, we investigated the anticonvulsant effects of Viola tricolor (V. tricolor) on seizure models induced by pentylenetetrazol (PTZ) and maximal electroshock stimulation (MES). Methods: Totally, 260 mice were ...

Amitriptyline (AMT) was developed for the treatment of chronic and neuropathic pain. There is also evidence it may be useful in neurodegenerative disorders. In this regard, effect on experimental model seizures memory impairment caused by rats investigated present study. Seizures Wistar (200-250 g) were induced pentylenetetrazole (PTZ, 60 mg/kg, intraperitoneally (i.p.)). The anticonvulsant AMT...

The development of Green Transport Corridors (GTCs) is an important strategy to help a region achieve more sustainable solutions. When such GTCs are implemented, multimodal supply chains and environmentally-friendly alternatives for freight transportation through economically relevant hubs long-distance routes can be facilitated. Based on previous efforts evaluating single routes, this paper ai...

objective: nitric oxide (no) plays an important role both as a consequence and as a cause of epileptic seizures.regarding the central nervous system depressant effects of achillea wilhelmsii (a. wilhelmsii), as well the effects of the plant on no, this study was aimed to elucidatethe possible role for nitric oxide on the effects of hydroalcoholic extract of a. wilhelmsii on pentylenetetrazole (...

Transient hyperprolectinemia has been reported to follow unprovoked seizures. This study was conducted in 90 children aged 1-18 years of age. The study comprised of four groups: Group-1 consisted of children with epilepsy which was further subdivided into GTCS, CPS and SPS. Group-2 comprised of children having febrile convulsions. Group-3 comprised of children suffering from non-epileptic parox...

Mutations in the leucine-rich, glioma inactivated 1 (LGI1) gene have been identified in patients with autosomal dominant lateral temporal lobe epilepsy (ADLTE). We previously reported that Lgi1 mutant rats, carrying a missense mutation (L385R) generated by gene-driven N-ethyl-N-nitrosourea (ENU) mutagenesis, showed generalized tonic-clonic seizures (GTCS) in response to acoustic stimuli. In the...

Purpose: Patients with self-limited epilepsy centrotemporal spikes (SLECTS) rarely experience generalized tonic-clonic seizures (GTCS) after remission, and post-remission GTCS has not been thoroughly described in earlier studies. Herein, we describe the clinical electrographic features of a substantial period seizure freedom patients SLECTS.Methods: This study included six (three boys three gir...

We read with interest the paper by Destina Yalcin et al. describing four patients with eyelid myoclonia associated with absences, myoclonic jerks and generalized tonic—clonic seizures (GTCS), and showing electroclinical features compatible with the diagnosis of either eyelid myoclonia with absences (EMA) and juvenile myoclonic epilepsy (JME). The authors suggest that EMA and JME are dynamic syn...