Abstract Introduction Sodium–glucose cotransporter 2 (SGLT2) inhibitors have been shown to slow the decline of kidney function in outcome trials, but biological mediator(s) underlying therapeutic benefit are not well established. Purpose We performed a post-hoc analysis exploring potential mediators effects SGLT2 inhibitor ertugliflozin on VERTIS CV exploratory composite (sustained 40% decrease...

Abstract Background and Aims Higher ambient temperatures have been associated with higher rates of admission for kidney stones acute injury. Occupational heat stress is also a risk factor impaired function in several rural resource-poor settings. It unclear if exposure faster loss patients established, all-cause, chronic disease (CKD). We therefore undertook post-hoc analysis the DAPA-CKD trial...

Abstract Introduction Sodium-glucose cotransporter 2 (SGLT2) inhibitors reduce risk of hospitalisation for heart failure (HHF) in outcome trials, but the biological mediators underlying therapeutic benefit are not well established. Purpose To identify potential through which ertugliflozin reduces HHF. Methods In VERTIS CV, 8246 patients with type diabetes and atherosclerotic cardiovascular dise...

BACKGROUND The co-circulation of 4 DENV serotypes in geographically expanding area, has resulted in increasing occurrence of DENV co-infections. However, studies assessing the clinical impact of DENV co-infections have been scarce and have involved small number of patients. This study explores the impact of DENV co-infection on clinical manifestations and laboratory parameters. METHODS This r...

Abstract Background Sodium-glucose co-transporter-2 (SGLT2) inhibitors are a newly recommended treatment of heart failure with reduced ejection fraction (HFrEF). The consistently observed increase in haematocrit SGLT2 inhibition is associated large proportion the clinical benefit different type 2 diabetes (T2D) populations. Whether caused by diuresis-associated haemoconcentration or due to dire...

Introduction The total testing process, which begins with the order of the physician, includes the preanalytical, analytical and postanalytical phases and ends with the results ready for interpretation. To obtain a reliable test result requires detection of all steps however, to control the preanalytical stage is such a complex way that much of the steps are human dependent and out of the labor...

to phenprocoumon and this was continued for 4 Case report months. Treatment with prednisone, albumin and furosemide A 5-year-old patient with idiopathic nephrotic synresulted in complete remission of the nephrotic syndrome had been successfully treated with a course of drome. Two years later the patient is free of neurologsteroids. Four months later the patient had a first ical residues. relaps...

BACKGROUND Ovarian hyperstimulation syndrome (OHSS) is an iatrogenic and potentially life threatening condition resulting from excessive ovarian stimulation. Reported incidence varies from 1% to 10% of in vitro fertilization (IVF) cycles. The factors contributing to OHSS have not been completely explained. The release of vasoactive substances secreted by the ovaries under human chorionic gonado...

Abstract Background and Aims Indole-3-acetic acid (IAA, also called auxin) is a protein-bound indolic uremic toxin deriving from tryptophan metabolism by the intestinal bacteria. Previous studies have shown that increased IAA associated with enhanced tissue factor synthesis in endothelial peripheral blood mononuclear cells, oxidative stress inflammation resulting higher risk of thrombotic event...

The ovarian hyperstimulation syndrome (OHSS) is a consequence of superovulation therapy for assisted conception procedures. This potentiallyfatal condition is avoidable by the judicious use of gonadotropins and carefulmonitoring of stimulation regimens. Women who are at particular risk ofdeveloping the syndrome include those who have polycystic ovaries and thosewho are young (under 30 years). W...