Central haemodynamics in 23 patients with mitral stenosis and 7 control subjects were compared with the results of regional lung perfusion studied by (133)Xe, pulmonary scintigraphy with (99)mTc-labelled macro-aggregates of albumin, and regional ventilation by (133)Xe.A close correlation was found between both methods assessing regional pulmonary perfusion, i.e. pulmonary scintigraphy and (133)...

The interest in, and the need for effective measures to be used in screening, diagnosis, and the follow-up of skeletal pathologies is growing markedly. This paper proposes a completely new and non-invasive technique allowing the study of the human tibia bone marrow (BM) haemodynamics with a time resolution of 1 s. The technique, based on near infrared spectroscopy, is sensitive enough to allow ...

The aim of this double-blind, placebo-controlled study was to determine whether acute administration of almitrine enhances hypoxic pulmonary vasoconstriction in patients with chronic obstructive pulmonary disease (COPD). Haemodynamics and blood gases were studied at various inspiratory fractional concentrations of oxygen (FIO2): 0.15, 0.21, 0.30 and 1.0, randomly administered for 20 min periods...

The organs of the hepatosplanchnic system are considered to play a key role in the development of multiorgan failure during septic shock. Impaired oxygenation of the intestinal mucosa can lead to disruption of the intestinal barrier, which may promote a vicious cycle of inflammatory response, increased oxygen demand and inadequate oxygen supply. Standard septic shock therapy includes supportive...

Reports of pulmonary hypertension in obese women treated with the appetite suppressant aminorex (Menocil) prompted this study using the calf as a model because of its very reactive pulmonary vascular bed. Acute and chronic haemodynamic effects were observed following daily intravenous injections of aminorex (0-25 mg/kg as free base) in four calves. Four other calves were similarly treated with ...