Southern blot analyses of genomic DNA show that new world monkeys have only one haptoglobin gene but that chimpanzees, gorillas, orangutans, and old world monkeys have three. Humans have two: haptoglobin (Hp) and haptoglobin-related (Hpr). These observations suggest that a triplication of the haptoglobin locus occurred after the divergence of the new world monkeys, followed by a deletion of one...

It is well established that hemoglobin resulting from red cell lysis binds to haptoglobin in plasma to form a complex. The increased molecular size precludes its filtration by the kidneys, redirecting it toward hepatocellular entry. Chemically cross-linked hemoglobins are designed to be resistant to renal excretion, even in the absence of haptoglobin. The manner in which binding to haptoglobin ...

DIABETES IS AN INDEPENDENT RISK FACTOR FOR THE DEVELOPMENT OF CARDIOVASCULAR DISEASE (CVD),1,2 AND A GROWING BODY OF EVIDENCE SUGGESTS THAT sleep-disordered breathing (SDB) is associated with adverse CVD risk factors and outcomes, including hypertension and myocardial infarction.1-5 The prevalence of hypertension, atherosclerotic CVD, and myocardial infarction are elevated in individuals with d...

preterm birth means the birth before thirty seven week of pregnancy that causes a lot of complications for the baby. variety factors are suggested to be involved in disease. in this study, we decided to evaluate haptoglobin (hp) phenotypes association with clinical features of patients suffered from premature delivery to understand better the possible correlation of genetic and clinical feature...

Over a period of three years we determined haptoglobin levels by single radial immunodiffusion (RID) and the haptoglobin phenotype in over 1700 samples of patients suspected of a haemolytic disease. As haptoglobin phenotyping is rather laborious and therefore an expensive method, we re-evaluated the diagnostic need for phenotyping. From our reference values for the respective phenotypes of hapt...

Haptoglobin is one of acute phase glycoproteins often used as markers in glycopathology studies. In this work the oligosaccharide structures of haptoglobin from 'healthy' subjects have been studied in detail, taking into consideration the possible dependence of glycosylation on the phenotype. About 75% of charged haptoglobin glycans were of biantennary complex structure, and some of them lacked...

1. A procedure for the rapid, accurate estimation of haptoglobin in serum and purified preparations is described, based on the peroxidase activity of haemoglobin in its complexes with haptoglobin. 2. Hydrogen peroxide, guaiacol and methaemoglobin reagents are used, under well-defined conditions which reduce the peroxidase activity of free haemoglobin essentially to zero. The reaction is followe...

PURPOSE Changes in concentrations of acute phase proteins in the serum of patients might be significant in the pathogenesis of Behçet disease. This report investigates the association between ocular disease activity and serum haptoglobin levels in patients with Behçet disease, and summarizes the current understanding of the correlation between acute phase proteins and Behçet disease based on bo...

Ecologists sometimes assume immunological indices reflect fundamental attributes of individuals-an important assumption if an index is to be interpreted in an evolutionary context since among-individual variation drives natural selection. Yet the extent to which individuals vary over different timescales is poorly understood. Haptoglobin, an acute phase protein, is an interesting parameter for ...

INTRODUCTION Despite implementation of the biological passport to detect erythropoietin abuse, a need for additional biomarkers remains. We used a proteomic approach to identify novel serum biomarkers of prolonged erythropoiesis-stimulating agent (ESA) exposure (Darbepoietin-α) and/or aerobic training. TRIAL DESIGN Thirty-six healthy young males were randomly assigned to the following groups:...