نتایج جستجو برای: hazard ratio
تعداد نتایج: 535796 فیلتر نتایج به سال:
OBJECTIVE To examine, following statewide dissemination, the influence of an evidence-based home visitation program for first-time mothers on reductions of subsequent pregnancies across time and different locations. DESIGN Retrospective cohort study. SETTING Replication sites for the Nurse-Family Partnership (17 urban sites and 6 rural sites) across the Commonwealth of Pennsylvania between ...
OBJECTIVE To investigate the relative predictive value of CD4(+) metrics for serious clinical endpoints. DESIGN Observational. METHODS Patients (3012; 20 317 person-years) from control arms of ESPRIT and SILCAAT were followed prospectively. We used Cox regression to identify CD4(+) metrics (latest, baseline and nadir CD4(+) cell count, latest CD4(+)%, time spent with CD4(+) count below cert...
BACKGROUND Edoxaban is a direct oral factor Xa inhibitor with proven antithrombotic effects. The long-term efficacy and safety of edoxaban as compared with warfarin in patients with atrial fibrillation is not known. METHODS We conducted a randomized, double-blind, double-dummy trial comparing two once-daily regimens of edoxaban with warfarin in 21,105 patients with moderate-to-high-risk atria...
BACKGROUND The duration of gastrointestinal colonization with extended-spectrum β-lactamase-producing Enterobacteriaceae (ESBL-E) may play a major role in the spread of these organisms. We evaluated the time to, and factors associated with, ESBL-E clearance after hospital discharge. METHODS We retrospectively reviewed prospective surveillance results obtained over 14 years in a 1,000-bed hosp...
The ultimate seizure outcome of childhood epilepsy is complete resolution of all seizures without further treatment. How often this happens and how well it can be predicted early in the course of epilepsy could be valuable in helping families understand the nature of childhood epilepsy and what to expect over time. In the Connecticut study of epilepsy, a prospective cohort of 613 children with ...
BACKGROUND Before 1971, several million women were exposed in utero to diethylstilbestrol (DES) given to their mothers to prevent pregnancy complications. Several adverse outcomes have been linked to such exposure, but their cumulative effects are not well understood. METHODS We combined data from three studies initiated in the 1970s with continued long-term follow-up of 4653 women exposed in...
The Landslide is one of the natural hazards that causes a lot of mortal and financial losses in high-altitude and seismic mountainous areas annually. Considering the importance of roads as a pillar of sustainable forest management in this study, we have tried to estimate the sensitivity of landslide occurrence in 8 forestry series with using frequency ratio approach. Initially, the slip positio...
PURPOSE The high mobility group box 1 (HMGB1) protein has roles in apoptosis and immune responses by acting as a ligand for receptor for advanced glycation end products (RAGE), Toll-like receptors (TLRs), and triggering receptor expressed on myeloid cells 1. In particular, HMGB1/RAGE is involved in tumor metastasis by inducing matrix metalloproteinase 2 (MMP2) and MMP9 expression. We investigat...
BACKGROUND A neuroprotective effect of dietary antioxidants on Parkinson's disease (PD) risk has been suggested, but epidemiological evidence is limited. OBJECTIVES To examine the associations between intake of dietary antioxidant vitamins and total antioxidant capacity and risk of PD. METHODS We prospectively assessed the relationships of dietary antioxidant vitamins C and E, ß-carotene, a...
BACKGROUND Infected central venous catheters cause morbidity and mortality. OBJECTIVE To compare the risk for colonization of central venous catheters used for total parenteral nutrition with that of catheters used for other purposes. METHODS Retrospective review of prospectively acquired data on 260 patients with a stay in a surgical intensive care unit longer than 3 days. Single-lumen cat...
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