Background: Matrix metalloproteinases (MMPs) and their inhibitors, tissue inhibitors of metalloproteinases (TIMPs) are regulators of extracellular matrix (ECM). Diabetes Mellitus (DM) is associated with abnormal cardiac ECM composition, which may contribute to the high incidence of myocardial dysfunction (typically diastolic dysfunction). We hypothesised that plasma MMP-9, TIMP1 & -2, by regula...

UNLABELLED Disturbances of glucose metabolism are frequently observed in patients with acromegaly. Excess amounts of GH and IGF1 interacts with metabolic regulation, and indeed, GH hypersecretion is associated with hepatic and peripheral insulin resistance; this and also other mechanisms are involved in the development of diabetes mellitus. It can quickly improve if the levels of GH decline aft...

BACKGROUND Chronic kidney disease (CKD), a condition frequently attributed to uncontrolled diabetes and hypertension, has become an economic and public health burden both globally and locally. The present study was designed to investigate the toxic effects of lead and hypertension (HTN) on chronic renal failure (CRF). METHOD It was a cross-sectional, prospective study conducted in Jinnah Post...

BACKGROUND Diabetes is one of the most common endocrine disorders characterized by hyperglycaemia. Diabetic nephropathy is a consequence of long standing diabetes. The prevalence of microalbuminuria predicts progression to diabetic nephropathy. The present study was conducted to determine the prevalence of microalbuminuria in relation to duration of diabetes, BMI, Serum Creatinine and HbA1c in ...

Exenatide is an incretin mimetic that acts through glucagon-like peptide 1 receptor accepted as a successful novel glucose-lowering agent in type 2 diabetes. The aim of this study was to explore the possible predictive factors for exenatide efficacy among baseline characteristics of type 2 diabetic patients. We observed basic anthropometric measurements, laboratory findings and diabetic complic...

OBJECTIVE To determine the frequency of erectile dysfunction in married male Type-2 diabetic patients. METHODS The cross-sectional observational study was carried out at the Endocrinology, Diabetes and Metabolic Diseases Unit Hayatabad Medical Complex, Peshawar, from July 2011 to Apr 2012, comprising 217 male married Type-2 diabetic patients. Serum samples were assayed for blood glucose, lipi...

Anyone who has looked through sequential outpatient clinic letters will be in no doubt in which area the next major improvement in management of diabetes will transpire. The procrastination of positive action until the HbA1, result is available, often in conjunction with seemingly favourable home blood glucose monitoring data, renders the measurement almost useless unless the patient is seen ag...

BACKGROUND Few studies have examined the management of comorbidities in cancer patients. This study used population-based data to estimate the guideline concordance rates for diabetes management before and after cancer diagnosis and examined if diabetes management services among cancer patients was associated with characteristics of the hospital where the patient was treated. METHODS We linke...

OBJECTIVE Language barriers may be significant contributors to diabetes disparities. We sought to assess the association of English speaking ability with glycemic control among Latinos with diabetes. METHODS We analyzed 167 Latinos from a cross-sectional survey of adults with type 2 diabetes. The main outcome was HbA1c > or =7.0%. The main predictor was self-reported English speaking ability....