In September 2001, during follow-up at our outpatient liver unit we detected by ultrasound a hypervascular mass adjacent to the VI hepatic segment in a 78-year-old HCV-positive cirrhotic woman. Subsequently abdominal computed tomography (CT) revealed an infiltrative vascularized nodule (3.5 cm in diameter) at the lower border of the VI hepatic segment and magnetic resonance imaging showed a “te...

Hepatocellular cancer (hcc) is the 2nd most frequent cause of cancer-related death in men and the 6th in women1. In 2008, the number of new liver cancer cases was estimated to be 748,300 worldwide, and 695,900 deaths were attributed to liver cancer that same year1. Overall, liver transplantation, surgical resection, and locoregional therapies are the treatment options for hcc. However, only a s...

background: light chain (lc) and heavy chain carboxyterminal subdomain (hcc) fragments are the most important parts of tetanus neurotoxin (tent) which play key roles in toxicity and binding of tent, respectively. in the present study, these two fragments were cloned and expressed in a prokaryotic system and their identity was confirmed using anti-tent specific polyclonal and monoclonal antibodi...

conclusions this information provides an explanation for the previously valuable literature on the functions of lncrnas and suggest for the novel therapeutic targeting. results the lncrnas hottip, h19, hotair, malat1, antisense igf2r (air), hoxa13, gtl2 (also called meg3) and uc002mb have been reported in association with hcc. besides, this study predicted that eif4aiii, ptb and fus were the mo...

conclusions the established method has an acceptable performance in quantifying yb-1. in addition, serum yb-1 may aid in the diagnosis of hcc. results the developed method was linear to 150 μg/l of yb-1 with a minimum detection limit of 0.01 μg/l. the average recoveries were between 93.9% and 109.0%. the mean intra- and inter-assay coefficients of variation (cvs) were 4.0-4.8% and 8.2-10.2%, re...

The incidence of non-alcoholic steatohepatitis (NASH)-related hepatocellular carcinoma (HCC) is increasing annually as the metabolic syndrome factors increase. This study aimed to analyze involvement periodontopathic bacteria in NASH-related HCC (NASH-HCC). Questionnaire investigation, periodontal examination, medical and specimen collection (saliva, mouth-rinsed water, peripheral blood) were p...

results the tlr3 protein in the ach group tended toward reduction although the p value of the comparison between the ach group and hd group was not statistically significant. the tlr3 levels in the hcc, ac, and cir groups were higher than those in the hd and ach groups. tlr3 was not interrelated with all costimulation proteins in the dcs and t cells in all five groups. no group presented any in...

(HCC) is the second most common cause of cancer-related death worldwide [1], generally arising on the background of chronic liver diseases such as chronic viral hepatitis, alcohol-induced liver injury, or fatty liver disease. So far, classification proposals for HCC based on molecular markers are not yet routinely applied in surgical pathology or clinical management of HCC patients. This stands...