BACKGROUND A relevant proportion of human immunodeficiency virus (HIV) infected patients is co-infected with the hepatitis C virus (HCV). HCV co-infection in HIV-positive patients is associated with faster progression of liver disease in comparison to HCV mono-infection. Natural killer (NK) cells critically modulate the natural course of HCV infection. Both HIV and HCV mono-infection are associ...

results among the 181 anti-hcv ab negative patients, 13 (7.2%) were positive for hcv core ag and 11 (6%) had detectable hcv rna with a range of 40-336543 iu/ml by pcr. the two tests had a high measurement agreement (kappa=0.82, p<0.001). of the 13 patients with positive hcv core ag test results, 3 were negative for hcv rna. considering real time pcr for hcv rna as the gold standard for hcv infe...

BACKGROUND Prevalence rates of hepatitis C virus (HCV) co-infection, the distribution of HCV genotypes, and the frequency of spontaneous resolution of hepatitis C in patients infected with the Human Immunodeficiency Virus (HIV) have a worldwide disparity. The purpose of this study is to investigate the prevalence of HCV antibodies (anti-HCV) in patients with HIV, the proportion and correlates o...

BACKGROUND Injecting drug users (IDUs) in Taiwan contributed significantly to an HIV/AIDS epidemic in 2005. In addition, studies that identified risk factors of HCV/HIV co-infection among IDUs were sparse. This study aimed to identify risk factors of HCV/HIV co-infection and HCV mono-infection, as compared with seronegativity, among injecting drug users (IDUs) at a large methadone maintenance t...

An estimated 3.2 million persons in the United States have chronic infection with hepatitis C virus (HCV). Most new HCV transmissions occur among persons who inject drugs, often within the first few years of their injection drug use. During 2003-2012, reports of HCV infection increased from 15 to 54 cases per 100,000 among persons aged <30 years in Wisconsin, and 58% of persons in this age grou...

BACKGROUND Occult Hepatitis C virus (HCV) infection is a new pathological entity characterized by presence of liver disease and absence or very low levels of detectable HCV-RNA in serum. Abnormal values of liver enzymes and presence of replicative HCV-RNA in peripheral blood mononuclear cells are also observed. Aim of the study was to evaluate occult HCV occurrence in a population unselected fo...

BACKGROUND Infection with human immunodeficiency virus (HIV) influences the outcome and natural disease progression of hepatitis C virus (HCV) infection. While the majority of HCV mono-infected and HCV/HIV co-infected subjects develop chronic HCV infection, 20-46% of mono- and co-infected subjects spontaneously clear HCV infection. The mechanism underlying viral clearance is not clearly underst...

normal 0 false false false en-us x-none ar-sa background: hepatitis c virus (hcv) is the main causative agent of post-transfusion hepatitis. the virus is distributed worldwide with varying prevalence in different countries, which could easily lead to chronic infections, cirrhosis, and even hepatocellular carcinoma. the aim of this study was to investigate prevalence of hcv infection and its tre...

BACKGROUND We and others have shown that primary hepatitis C (HCV) infection in men infected with human immunodeficiency virus (HIV) causes early-onset liver fibrosis; however, little is known about the long-term natural history of the liver disease in these HIV-infected men. METHODS We followed a cohort of HIV-infected men with primary HCV infection in New York City. RESULTS Four men who w...

objective: despite sensitive antibody based blood donor screening, infection can be transmitted during window period. therefore sensetive methods bosed on nucleic acid tests (nats) have been considered. the aim of this project was to design a more sensitive method for detection of pcr products and diagnosis of hiv-1/hcv co-infection accurately. materials and methods: after designing specific p...