OBJECTIVE Although cerebellar hemorrhagic injury is increasingly diagnosed in infants who survive premature birth, its long-term neurodevelopmental impact is poorly defined. We sought to delineate the potential role of cerebellar hemorrhagic injury in the long-term disabilities of survivors of prematurity. DESIGN We compared neurodevelopmental outcome in 3 groups of premature infants (N = 86;...

BACKGROUND AND PURPOSE An abnormal expression of some matrix metalloproteinases (MMPs) is related with hemorrhagic transformation events after stroke. Our aim was to investigate MMP-2 and MMP-9 in the ischemic brain and its relation with blood-brain barrier breakdown after hemorrhagic transformation in human stroke. METHODS We assessed 5 cases of fatal ischemic strokes with hemorrhagic compli...

BACKGROUND We aimed at determining the overall incidence and risk of hemorrhagic events associated with vascular endothelial growth factor receptor-tyrosine-kinase inhibitors (VEGFR-TKIs). METHODS We searched PubMed, EMBASE and Cochrane library databases for relevant prospective, randomized controlled trials (RCTs). Statistical analyses were conducted to calculate the summary incidence, relat...

BACKGROUND & OBJECTIVES Crimean - Congo hemorrhagic fever is an acute viral hemorrhagic fever with considerable mortality. Despite increasing knowledge about hemorrhagic fever viruses, the pathogenesis of Crimean -Congo hemorrhagic fever and causes of death were not well described. We aimed to evaluate whether there were electrocardiographic parameters designating mortality among these patients...

OBJECTIVE Crimean-Congo hemorrhagic fever is an acute viral hemorrhagic fever with a high mortality rate. Despite increasing knowledge about hemorrhagic fever viruses, little is known about the pathogenesis of Crimean-Congo hemorrhagic fever. In this study, we measured serum adenosine deaminase and xanthine oxidase levels in Crimean-Congo hemorrhagic fever patients. METHODS Serum adenosine de...

since 1999, many cases of crimean-congo hemorrhagic fever have been reported from different parts of iran. this study intended to define cchf seroprevalence, incidence rates, and the most important risks in sistan- baluchestan province, iran. using cluster sampling with probability proportional to size, 310 subjects were selected from various districts of zahedan and zabol in the northern part ...

background: crimean-congo hemorrhagic fever (cchf) is a disease characterized by serious course, including acute viral fever, ecchymosis, thrombocytopenia, liver dysfunction and high rate of mortality. hypoxia inducible factor-1α (hif-1α) and vascular endothelial growth factor-a (vegf-a) play an important role both in the inflamma­tory process and plasma leakage. the aim of this study was to de...

introduction: during hemorrhagic shock (hs), the kidneys are one of the primary target organs involved. oxidative stress is shown to be enhanced in different models of acute kidney injury (aki). remote ischemic preconditioning (rpc) by brief limb ischemia is considered to be a safe method to protect different organs from further damage. in this study, we investigated the effects of brief hind l...

case presentation this article presents a 56-year-old woman from guilan province, the north of iran and the southern coast of the caspian sea, who admitted to the hospital with acute fever, severe headache, thrombocytopenia, anemia, epigastric pain, myalgia, nausea and vomiting. conclusions we recognized that the case was co-infected by cchf and leptospirosis. introduction infectious diseases a...

ebola hemorrhagic fever (ehf) was first reported in 1976 with two concurrent outbreaks of acute viral hemorrhagic fever centered in yambuku (near the ebola river), democratic republic of congo, and also in nzara, sudan. the current outbreak of the ebola virus was started by reporting the first case in march 2014 in the forest regions of southeastern guinea. due to raising infection rates of ove...