Methods Pediatric patients of Caucasian Italian origin with the following diseases/manifestations were included in the study: i) histologically confirmed polyartiritis nodosa (PAN) or cutaneous polyartiritis nodosa (cPAN), ii) persistent livedo reticularis with elevation of acute phase reactants, iii) ischemic or hemorrhagic strokes with systemic inflammation. Direct sequencing of CECR1 gene (e...

BACKGROUND The use of aspirin to prevent cardiovascular disease events in patients without a history of cardiovascular disease is controversial. PURPOSE To examine the benefits and harms of aspirin chemoprevention. DATA SOURCES MEDLINE (1966 to May 2001). STUDY SELECTION 1) Randomized trials at least 1 year in duration that examined aspirin chemoprevention in patients without previously k...

BACKGROUND AND PURPOSE Stroke patients with hemorrhagic (HS) and ischemic strokes were compared with regard to stroke severity, mortality, and cardiovascular risk factors. METHODS A registry started in 2001, with the aim of registering all hospitalized stroke patients in Denmark, now holds information for 39,484 patients. The patients underwent an evaluation including stroke severity (Scandin...

A 67-year-old hypoxic woman was admitted following two episodes of cerebral infarction. Based on the clinical presentation and radiological findings, a diagnosis of hereditary hemorrhagic telangiectasia was made and the cerebral ischemic complications were considered to have been caused by paradoxical embolizations related to pulmonary arteriovenous malformations (PAVMs). We performed video-ass...

#### Notable in Neurology This Week This issue features an article that investigates the association of depression and anxiety with cognitive impairment patients 6 months after stroke; another explores utility olfactory testing screening for Parkinson disease REM behavior disorder. A featured Views & Reviews examines CSF blood neurofilament levels neuronal brain damage athletes who play physic...

BACKGROUND AND PURPOSE Selective serotonin reuptake inhibitors (SSRIs) have been associated with an increased risk of bleeding but also a possible neuroprotective effect in stroke. We aimed to examine the implications of prestroke SSRI use in hemorrhagic and ischemic stroke. METHODS We conducted a registry-based propensity score-matched follow-up study among first-ever patients with hemorrhag...

BACKGROUND AND PURPOSE Epidemiological studies have documented that plasma d-dimer, a fibrin degradation product, is a risk marker for coronary heart disease, but there is limited prospective evidence for stroke. Given that thrombosis is a key mechanism for many strokes, we studied whether d-dimer is a risk marker for ischemic stroke incidence in the Atherosclerosis Risk in Communities (ARIC) S...

Aim . To analyze inhospital outcomes of carotid endarterectomy (CE) in the acute period (within 3 days from onset) ischemic stroke. Material and methods This retrospective multicenter study for January 2008 to August 2020 included 357 patients who underwent CE An interdisciplinary commission defined revascularization timing. There were following inclusion criteria: 1. Mild neurological disorder...