background a potential treatment for healing hepatic tissue is delivering isolated hepatic cells to the site of injury to promote hepatic cells formation. in this technology, providing an appropriate injectable system for delivery of hepatic cells is an important issue. in this regard, fibrin scaffolds were designed with many advantages over other scaffolds like cell delivery vehicles for biode...

groups, i.e., the group with less than 30 per cent of interstitial tissue and the group with 30 per cent or more of interstitial tissue. Edema, liver enlargement, abnormalities in thymol flocculation test, in cephalin cholesterol flocculation test, and in serum r-globulin concentration, and deformity of the hepatic veins in hepatic venograms were all significantly more frequently observed in th...

We previously reported that nitric oxide (NO) derived from endothelial NO synthase (NOS) increased endothelial prostacyclin (PGI(2)) production in rats subjected to hepatic ischemia-reperfusion (I/R). The present study was undertaken to determine whether neutrophil elastase (NE) decreases endothelial production of PGI(2), thereby contributing to the development of I/R-induced liver injury by de...

Peripheral blood and hepatic tissue T- and B-lymphocyte distributions, serum alpha fetoprotein (AFP) concentrations, and hepatic AFP were studied in 46 patients undergoing diagnostic percutaneous liver biopsy. The patients included 26 with alcoholic liver disease, 13 with nonalcoholic hepatitis or cirrhosis, and 7 with either normal histology or minor nonspecific changes. Serum AFP was determin...

Recent work has demonstrated that the formation of platelet neutrophil complexes (PNCs) affects inflammatory tissue injury. Vasodilator-stimulated phosphoprotein (VASP) is crucially involved into the control of PNC formation and myocardial reperfusion injury. Given the clinical importance of hepatic IR injury we pursued the role of VASP during hepatic ischemia followed by reperfusion. We report...

Hepatic fibrosis is one of the common pathological features of chronic liver disease. Atorvastatin and naltrexone previously showed a beneficial effect on hepatic fibrosis. In the present study, we compared the effect of atorvastatin and naltrexone on a rat model of hepatic fibrosis induced by BDL. Methods: This study was carried out on 4 groups each of 10 albino rats; Group 1: Sham operated gr...

Several human diseases including, cancer, rheumatoid arthritis, neurodegenerative and hepatic diseases are related to destructive effect of reactive oxygen species (ROS). Antioxidants may provide a possible solution to this problem.This study was carried out to investigate the effect of hydroalcoholic extract of Celtis australis on CCl4 induced hepatotoxicity in mice.  The antioxidant activity...