OBJECTIVE To determine dynamic Gc-globulin level change in Acute-on-Chronic Hepatitis B Liver Failure (ACHBLF) patients, and evaluate the prognostic value of Gc-globulin. STUDY DESIGN An analytical study. PLACE AND DURATION OF STUDY The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China, from January 2010 to December 2012. METHODOLOGY A total of 54 consec...

We analyze the case of a 49-year-old male patient who presented with clinical signs acute hepatitis an initial suspicion autoimmune etiology. Laboratory findings demonstrated positive antinuclear antibody, anti-smooth muscle antibody and high serum gamma globulin. Histology liver biopsy revealed changes compatible hepatitis, which associated International Autoimmune Hepatitis Group score 7, det...

From 1982 to 1989, pregnant women in two large city hospitals in The Netherlands had serum samples screened for hepatitis B surface antigen (HBsAg). Infants of mothers found to be HBsAg-positive received hepatitis B immune globulin immediately after birth and hepatitis B vaccine in the first year of life. Blood samples of infants were regularly tested for HBsAg and antibodies directed against H...

Long-term hepatitis B immune globulin (HBIG) has been shown to reduce hepatitis B virus (HBV) reinfection in patients transplanted for hepatitis B. The aim of this study was to determine the prevalence of HBV S gene mutations in liver transplant recipients who developed recurrent hepatitis B despite HBIG prophylaxis, and to determine if these mutations can revert after withdrawal of HBIG. The e...

The prevention of the spread of hepatitis B is of utmost importance to the dental profession. The mechanisms of transmission of the virus between practitioner and patient are discussed and preventive options outlined. Despite conscientious history taking, not all virus carriers can be identified without laboratory screening of the entire population. Despite specific precautions high risk exposu...

BACKGROUND Hepatitis B virus (HBV) infection is endemic in China; perinatal transmission is the main source of chronic HBV infection. Simultaneous administration of hepatitis B immune globulin (HBIG) and hepatitis B vaccine is highly effective to prevent perinatal transmission of HBV; however, the effectiveness also depends on full adherence to the recommended protocols in daily practice. In th...

To further evaluate thyroid function in patients with liver disease, we have measured total and free T3 and T4, thyroxine binding globulin, basal and thyrotropin releasing hormone-stimulated thyrotropin and thyroglobulin antibodies in 33 patients with liver cirrhosis, in 22 with chronic hepatitis and in 30 healthy controls. All the patients but one were clinically euthyroid. T3, FT3, T3/thyroxi...

1. Hepatitis B virus variants with antiviral drug-resistant mutations and/or hepatitis B immune globulin-resistant mutations are the main cause of hepatitis B virus reinfections post-liver transplant. 2. Early diagnosis of antiviral drug resistance and prompt initiation of rescue therapy are important in preventing hepatitis flares and hepatic decompensation. 3. Virologic breakthrough is the fi...