background and aims: viral hepatitis is a global health problem with a high mortality rate. recently, a new flavi-like virus, provisionally named hepatitis g virus (hgv), has been described. hgv does not induce an immune response that is consistently detectable by using recombinant proteins from prokaryotic expression, therefore studies have been conducted by using polymerase chain reaction (pc...

The impactful discovery and subsequent characterisation of hepatitis C virus (HCV), an RNA the flavivirus family, led to awarding 2020 Nobel Prize in Physiology or Medicine Harvey J [...]

materials and methods a case-control study was designed on 91 cases with spontaneous hcv infection clearance and 259 patients with persistent hcv infection as the control group. the rs12979860 snp was assessed as the most common ifnl polymorphism by pcr-rflp method. results distribution of rs12979860 cc genotype in the spontaneous clearance group was around two folds of its distribution in chro...

conclusions our investigation illustrated that the prevalence of hepatitis c was higher among olp patients compared to the control group. these findings are in line with previous results that reported a hepatitis c prevalence of 0.19% among the general population of mashhad. results of the 134 olp patients only three (2.23 %) had hcv infection where both anti-hcv and hcv-rna were positive. all ...

OBJECTIVE To determine the prevalence, target antigens and clinical associations of antineutrophil cytoplasmic antibodies (ANCA) in chronic hepatitis C without extrahepatic manifestations and in chronic hepatitis C virus (HCV)-associated mixed cryoglobulinemia (MC) in two European centers. METHODS 50 sera from patients with chronic hepatitis C and 116 sera from HCV-associated MC were tested f...

introduction : regular blood transfusions for patients with thalassemia major have improved their overall survival, but carry a definite risk of being infected with blood born viruses especially hepatitis b and c. nowadays, it has remained as main health concern about these patients. in this study, we tried to define the prevalence rate of hepatitis b and c and survey the related risk factors a...

  Background and Objective: Although transfusion therapy has lead to great improvement in longevity for hemophiliacs, but there have been tragic setbacks especially from transmission of human immunodeficiency virus (HIV) and hepatitis C virus (HCV) .HIV was reported to increase the rate of HCV-related liver failure by 4.2 times. In this study, we aimed to determine the seroprevalence of HIV an...

Four virological markers of hepatitis C virus (HCV) infection are used clinically for management of patients with hepatitis C, namely the HCV genotype, HCV RNA, HCV core antigen, and antibody to HCV (anti-HCV). The diagnosis of acute and chronic hepatitis C is based on both anti-HCV detection using enzyme immunoassays (EIA) and HCV RNA detection using a sensitive molecular biology-based techniq...

It is estimated that currently, in the world, approximately 3% of population has chronic hepatitis, hepatitis C virus etiological agent most related to development this pathology. The diversity genotypes (7) and quasi-species HCV, due its high mutation rate, interferes with an effective humoral immunity. aim work precisely evoke those usual drugs used HCV therapy, as well cutting-edge drugs. go...