This study was conducted to assess the preventive effect of aqueous extract of Berberis integerrima Bge. root (AEBIR) on liver damage and oxidative stress induced by diabetes mellitus in rats. Forty male rats were divided into 5 groups as follows: 1- normal (N); 2- normal + barberry (N+B) (they received barberry root extract for 6 weeks); 3- diabetic (D) (they received Streptozotocin (STZ), 65 ...

The present study incorporates a study of 42 cases of lepromatous leprosy for hepatic involvement and role of indigenous herbal preparation in protecting the liver in leprosy. Liver was enlarged in 32 cases which was tender in 8 patients. Alteration in liver function irrespective of extent and duration of the illness (3 months to 10 years with mean duration of illness = 2 years 5 months) was ma...

Chronic feeding of carcinogens p-dimethylamino azobenzene (initiator) and phenobarbital (promoter) for 90 and 120 days elevated activities of acid and alkaline phosphatases, levels of blood glucose and cortisol and decreased the activities of glutathione reductase, succinate dehydrogenase, and blood cholesterol and hemoglobin contents, and levels of serum estradiol and testosterone in mice. Lev...

Here we present a unique case of variation in the branching pattern of the coeliac trunk. In the present case, the coeliac trunk was replaced by two separate arterial trunks. The first arterial trunk bifurcated into the left gastric and the left hepatic arteries. The second arterial trunk bifurcated into a splenic artery and a hepato-gastroduodenal trunk. The hepato-gastroduodenal trunk present...

The current study was designed to investigate the possible mechanism involved in hyperglycemia induced by chronic exposure to deltamethrin (DLM) in rat and to assess whether this damage is amenable to modulation by Zygophyllum album. DLM, a synthetic pyrethroid pesticide, was administrated at a dose of 4 mg/kg body mass, during 60 days. Compared with control, DLM showed a significant increase o...

BACKGROUND The effect of α-tocopherol or simvastatin treatment on antioxidant defense in liver of old rats was investigated. METHODS Endogenous thiobarbituric acid reactive substances (TBARS) and total nitrite/nitrate (NO(2)/NO(3)) levels as well as non-enzymatic glutathione (GSH) and enzymatic antioxidants [glutathione-S-transferase (GST), superoxide dismutase (SOD), glutathione peroxidase (...

Flower extract of C. officinalis L. was evaluated for its protective effect against CCl4 induced acute hepatotoxicity and cisplatin induced nephrotoxicity. The activities of serum marker enzymes of liver injury like glutamate pyruvate transaminase (SGPT), glutamate oxaloacetate transaminase (SGOT) and alkaline phosphatase (ALP) which were increased by CCl4 injection was found to be significantl...

Chronic and acute alcohol exposure has been extensively reported to cause oxidative stress in hepatic and extra-hepatic tissues. Watermelon (Citrullus lanatus) is known to possess various beneficial properties including; antioxidant, anti-inflammatory, analgesic, anti-diabetic, anti-ulcerogenic effects. However, there is a lack of pertinent information on its importance in acute alcohol-induced...

Objective(s):  Oxytetracycline (OTC) is a broad spectrum antibiotic widely used for treatment of a wide range of infections. However, its improper human and animal use leads to toxic effects, including hepatonephrotoxicity. Our objective was to evaluate protective effects of Nigella sativa oil (NSO) and/or ascorbic acid (AA), against OTC-induced hepatonephrotoxicity in rabbits. Materials and Me...

Neem (Azadirachta indica) and Tamarind (Tamarindus leaves are used worldwide for their wide range of medicinal properties like antibacterial, antiprotozoal, hepato-protective other properties. The present study was conducted to observe the effects as anthelmintics in cattle. Animals were selected grouped into four groups where Group A considered control, B treated with grinded leaves,...