aim and background: hepatocellular carcinoma (hcc) -an aggressive malignancy with high rate of mortality- is the third cause of cancer related death, worldwide. cisplatin is a chemotherapy drug used for treatment of hcc. however, serious side effects of drug limit the therapeutic administer dose.  nanotechnology based devices such as liposome nanoparticles are capable to overcome these drawback...

Background: Hepatocellular carcinoma (HCC) is the one of most common cancers and lethal diseases in world. SORT1 a neuronal type-1 membrane protein member Vps10p-domain receptor family, which was abundantly expressed cells. However, effect on HCC progression remains unclear hepatocellular carcinoma. Material methods: Analysis various public omics datasets revealed that overexpressed HCC. Next, ...

Dipeptidyl peptidase (DPP) 9, DPP8, DPP4 and fibroblast activation protein (FAP) are the four enzymatically active members of S9b protease family. Associations DPP9 with human liver cancer, exonic single nucleotide polymorphisms (SNPs) in loss function (LoF) variants have not been explored. Human genomic databases, including The Cancer Genome Atlas (TCGA), were interrogated to identify LoF asso...

Reports of epidemiological studies of liver cancer relevant to these monographs have employed a variety of terms to describe this disease, for example, lIver cancer, primary liver cancer, primary hepatocellular carcinoma and hepatocellular carcinoma. We chose to use only the term hepatoceIIular carcinoma (HCC) in describing these studies. This choice was made because most of the studies have sp...

Hepatocellular carcinoma (HCC) is a highly metastatic primary liver cancer generating molecular alterations that end up escaping the apoptotic machinery and conferring multidrug resistance. Targeted medicines with increased selective cytotoxicity minimal drug resistance are essential for treatment of HCC. In this study, self-assembled polycationic (PC) amphiphilic β-cyclodextrin (βCDC6) nanopar...

Hepatocellular carcinoma (HCC) is a malignant tumor of the liver. Heat shock proteins play their part in response to cellular stress. They are overexpressed many forms cancers where they shield cells from stressful environment thus contributing poor prognosis and treatment resistance. HSP 27, heat protein mostly associated with Hepatitis induced hepatocellular cancer, inhibits apoptosis 70 alon...

Abstract Background Hepatocellular carcinoma (HCC) is one of the most dangerous cancers in all world. This study focused on prevention and therapy hepatocellular using Moringa oleifera extract combined with vitamin C selenium a nanoplatform (MO/asc.-Se-NPs). Results Full characterization MO/asc.-Se-NPs was performed by different analytical techniques (TEM, DLS, zeta-sizer), its antioxidant capa...

Hepatocellular carcinoma rarely metastasizes to the orbit. We report a 45-year-old male, HBV+, HIV+, with a past history of a liver transplant for ELSD (end-stage liver disease) with hepatocellular carcinoma and recurrent HCC, who presented with proptosis and diplopia of the left eye. CT scans of the head revealed a large, irregular mass in the left orbit causing superior and lateral destructio...

Development of Hepatocellular carcinoma (HCC) after Hepatitis C virus (HCV) infection is common cause of poor long-term survival. This study aimed to evaluate the effect of Vascular Endothelial growth factor (VEGF) genes polymorphism as a risk factor of Hepatocellular carcinoma (HCC) in chronic hepatitis C virus in Pakistani population. VEGF regulates angiogenesis so it is mainly involved in pr...