This study aimed to examine the hepatoprotective effects of the superfine particles of Radix Tetrastigma (SPRT) against CCl4-induced acute liver damage in rats. Animals were treated with SPRT (0.3, 0.6, and 1.2 g/kg) and showed remarkable hepatoprotection against CCl4-induced hepatotoxicity. CCl4 altered various biochemical parameters in rat liver, including alanine aminotransferase (ALT), aspa...

Hepatoprotective activity of hydroalcoholic extract of Luffa acutangula (HAELA) against carbon tetrachloride (CCl4) and rifampicin-induced hepatotoxicity in rats was evaluated and probable mechanism(s) of action has been suggested. Administration of standard drug- silymarin and HAELA showed significant hepatoprotection against CCl4 and rifampicin induced hepatotoxicity in rats. Hepatoprotective...

Solanum nigrum belonging to the family Solanaceae, has been considered as a remedy for treating various ailments like epilepsy, gastric ulcers etc. and is believed have hepatoprotective activities. In this study, total phenolic flavonoid content of extracts Ethyl acetate Methanol from leaves their antioxidant activity was carried out by using spectrophotometric methods. extract with high absorb...

Oleanolic acid (OA) is a pentacyclic triterpenoid widely found in plants and foods as an aglycone of saponins or free acid. OA exhibits beneficial activities for humans, including antitumor, antivirus, hepatoprotection properties without apparent toxicity. The metabolites produced by the cytochrome P450 (P450) enzymes are critical evaluation efficacy safety drugs. In this study, potential were ...

The ethanol and aqueous extracts of leaves of Neptunia Oleracea lour (Mimosaceae) were tested for their efficacy against carbon tetrachloride (CCl4) induced hepatotoxicity in Wistar albino rats. The different groups of animals were administered ethanol and aqueous extracts to carbon tetrachloride treated rats. In the present study ethanol extract (p<0.01) and aqueous extract (p<0.05) significan...

Hepatic IR (ischaemia/reperfusion) injury is an important clinical problem complicating liver surgery and transplantation. IPC (ischaemic preconditioning) is a strategy whereby brief episodes of IR in an organ can induce an adaptive response to protect against subsequent prolonged IR injury. However, trauma to vessels supplying the target organ is unavoidable using the technique of direct IPC. ...

A variety of rodent models of hepatoprotection have been developed in which tolerance to acetaminophen-induced hepatotoxicity occurs. Autoprotection/heteroprotection is a phenomenon where prior exposure to a mildly toxic dose of toxicant confers protection against a subsequently administered higher dose of the same toxicant (as in the case of autoprotection) or to a different toxicant (referred...