Background and Objective. High-cholesterol diet (HCD) intends to increase the oxidative stress in liver tissues inducing hepatotoxicity. Rutin is a natural flavonoid (vitamin p) which is known to have antioxidative properties. The aim of the present study was to investigate the potential effects of Rutin on hypercholesterolemia-induced hepatotoxicity in rats. Materials and Methods. Male Wistar ...

AIM The period of onset of hepatotoxicity varies between cohorts as do their clinical manifestations. Clinical manifestations of hepatotoxicity that have been previously reported include fatal portal hypertension, dress syndrome, and lipodystrophy syndrome. The aim of this study was to determine the period of onset and clinical manifestation of hepatotoxicity after commencing HAART. MATERIALS...

Cyclosporin A (CsA) is an immunosuppressant drug widely used in organ transplant recipients and patients with auto-immune disorders. Long-term treatment with CsA is associated with hyperlipidemia and an increased risk of atherosclerosis. The mechanisms by which cyclosporin A causes hyperlipidemia are unclear. Cell and animal studies have pointed to various mechanisms that may mediate CsA-induce...

conclusions anti-tuberculosis drugs-induced hepatotoxicity caused treatment interruption in 5.5% of the patients with tuberculosis. the majority of the patients with dih were above fifty, and 50% the cases occurred during the first two weeks after treatment onset. physicians must carefully and closely monitor such patients. background hepatotoxicity is one of the most frequent adverse events th...

background: age-related differences in the ethoxyresorufin o-deethylase (erod) activity of cyp1a1 and its inducibility in rats may determine the toxic potential of acetaminophen.  this study was carried out to compare the effects of acetaminophen (apap) and β-naphthoflavone (βnf) on cyp1a1 activity in young and adult rats. methods: for this purpose, young and adult rats (n = four / group) were...

Omega-3 from fish is commonly recommended for the control of hyperlipidemia, however, there are few studies in dogs proving its efficacy, and no have compared doses omega-3 patients with severe hyperlipidemia.

objective: acetaminophen (apap) overdose causes acute liver injuries. studies show that stem cell factor (scf) and its receptor, c-kit, enhance liver recovery from apap-induced injuries in mice. in this study we explore the effect of scf on activity of glutathione s-transferase (gsts) enzymes which are considered to be important in apap metabolism. methods: we divided 45 balb/c mice into three...

background: tuberculosis continues to be a common health problem worldwide. rifampin, an antibiotic used routinely for tuberculosis chemotherapy is documented to be a potent hepatotoxicant. the aim of the present study was to assess the antioxidant activity of ethanolic extract of crocus sativus l . stigma (eecsl.s) against rifampin induced hepatotoxicity in the rats. materials and methods: mal...