Calcineurin inhibitors (CNIs) are typically used to prevent organ rejection and their use has significantly improved allograft survival rates with a marked reduction in rates. However, CNIs have been associated various side effects including nephrotoxicity, hypertension, gingival hyperplasia, hypertrichosis, hepatotoxicity, hyperkalemia, neurotoxicity. Significant intra-patient interpatient pha...

Objective(s): 5-FU, an anticarcinogenic agent, is reported to have side-effects that include hepatotoxicity and nephrotoxicity. The study objective was to investigate the protective effects of naringin on 5-FU-induced hepatotoxicity and nephrotoxicity.Materials and Methods: Thirty rodents were assigned to three groups. The control group received 1 ml of intragastric distilled water for 14 days....