Using sophoridine 1 and chalcone 3 as the lead compounds, a series of novel α, β-unsaturated sophoridinic derivatives were designed, synthesized, and evaluated for their in vitro cytotoxicity. Structure-activity relationship (SAR) analysis indicated that introduction of α, β-unsaturated ketone moiety and heterocyclic group might significantly enhance anticancer activity. Among the compounds, 2f...

Background and objectives: Prosopis farcta has been used as a traditional herbal medicine for treating diabetes mellitus.The aim of this study was investigating the antidiabetic mechanisms of infusion extract of P. farcta and discovering the active extract for the first time. Methods: Six different extracts of P. farcta were ...

The present study evaluated the anti-depressant and antianxiety effect of standardized extract of Punica granatum (HEPG) in olfactory bulbectomy (OBX) induced depression and anxiety in rats. The surgery was performed in 30 male rats and was recovered by keeping in socialisolation condition for the period of 14 days followed by the treatment for next 14 days. Fluoxetine (10mg/kg, p.o), HEPG (10,...

The purpose of this study was to investigate the effect of ST2825, an inhibitor of myeloid differentiation factor 88 (MyD88), on the proliferation and apoptosis of human hepatocellular carcinoma (HCC) cells as well as the potential mechanism and clinical significance of ST2825 in the treatment of HCC. Immunohistochemical staining with an MyD88 antibody was performed on tissues from 80 human HCC...

Abstract Hepatocellular carcinoma (HCC), also known as hepatoma, is the most prevalent type of primary liver cancer. It begins in hepatocytes, liver’s major cell type. Cancer that began another region body but has spread to secondary cancer life; several still unmet demands for better, less toxic therapy treat this malignant tumor. Several novel pyrazolo[1,5- a ]pyrimidine derivatives were synt...

Three new diketopiperazines, dichotocejpins A-C (1-3), together with eight known analogues (4-11), were isolated from the culture of the deep-sea sediment derived fungus Dichotomomyces cejpii FS110. Their structures, including absolute configurations, were elucidated by a combination of HRESIMS, NMR, X-ray crystallography, and ECD calculations. Compounds 4-6, 10-11 showed significant cytotoxic ...