نتایج جستجو برای: hepg2
تعداد نتایج: 9165 فیلتر نتایج به سال:
Liver cancer is a progressive, irreversible and aggressive malignant disease, which has no effective chemotherapeutic drugs. RA-XII, a natural cyclopeptide isolated from the traditional Chinese medicine Rubia yunnanensis, exerts anti-cancer and anti-inflammatory activities. This work aimed to investigate the effects of RA-XII on a hepatic tumor and its underlying mechanisms in human hepatoma He...
مقدمه: از جمله مهم ترین گیرنده هایی که در بیماری هپاتوسلولار کارسینوما بیان بالایی پیدا می کنند، می توان به گیرنده های آسیالوگلیکوپروتئین اشاره کرد. با آراستن سیستم های حامل دارویی به لیگاندهای اختصاصی این گیرنده می توان اتصال آن ها را با سلول و در نتیجه جذب آن ها را به سلول های هپاتوما افزایش داد. این کار سبب کاهش عواض دارو در اندام های غیر هدف و افزایش اثربخشی دارو می شود. هدف از مطالعه ی حاض...
The aim of this study was to investigate the antioxidant properties root extract Onosma armeniacum and its cytotoxic effect against human liver (HepG2), lung (A549) colon (WiDr) cancer cell lines compared with a normal fibroblast line. Antioxidant determined using colorimetric methods. were investigated MTT assay. total phenolic content reducing power values 26.1±0.4 mg gallic acid equivalent 5...
OBJECTIVES In this study, we investigated the effect of grape seed proanthocyanidins extracts (GSPE), which have been proved to have anti-oxidative and anti-aging functions, on the expression of apoA-L at mRNA level of HepG2 cells in vitro under the experimental conditions of high-sugar and sugar. MATERIALS AND METHODS Cell viability was measured by sulforhodamine B (SRB). The apoA-I mRNA exp...
The new anti-cancer and water-soluble curcumin derivatives have been synthesized solvent-freely by functionalizing the phenolic group of with various NH compounds to increase water solubility cancerous properties. biological applications drugs investigated against highly potent HepG2 carcinoma cell line. studies showed that could be used in low concentrations (µM/l<1) avoid anti-apoptoti...
سابقه و هدف: نانوذرات نقره (AgNPs) دارای فعالیت ضد باکتری، ضد رگزایی و ضد سرطان می باشند. هدف از این مطالعه بررسی اثرات آپوپتوتیک AgNPs با پوشش عصاره برگ آویشن شیرازی بر سلول های سرطانی کبد، رده HepG2، می باشد. مواد و روش ها: سلول های سرطانی رده HepG2 با غلظت های مختلف AgNPs در زمان های 24 و 48 ساعت تیمار شدند. میزان زیست پذیری سلول ها و غلظت مهاری (IC50) با آزمونMTT محاسبه شد. جهت بر...
The aim of this study was to examine the effect of crude bile on the human HepG2 and CCRF-CEM cell lines. Cells were exposed to different dilutions of bile. Antiproliferative effects were determined by the cytotoxic MTT assay. Cells undergoing apoptosis were identified by terminal deoxynucleotidyl transferase dUTP nick end labeling (TUNEL) assay. Bile administration resulted in dose-dependent c...
Pigmented rice is mainly black, red, and dark purple, and contains a variety of flavones, tannin, polyphenols, sterols, tocopherols, γ-oryzanols, amino acids, and essential oils. The present study evaluated the cytotoxic effects of purple rice extracts (PREs) combined with chemotherapeutic drugs on human cancer cells and mechanisms of cell death. Methanolic (MeOH) and dichloromethane (DCM) extr...
OBJECTIVE The aim of this study was to explore the effects of β3-adrenoceptor (β3-AR) activation on HepG2 cells and its influence on cholesterol efflux from macrophage foam cells. MATERIALS AND METHODS HepG2 cells were cultured and treated with the β3-AR agonist, BRL37344, and antagonist, SR52390A, and the expression of apolipoprotein (Apo) A-I, ApoA-II, ApoB, and β3-AR in the supernatants an...
Hepatocyte growth factor (HGF), an antimitogenic factor for HepG2 cells, increased mRNA and protein levels of UGT1A1 and CYP2B6, as well as the endogenous cyclin-dependent kinase (CDK) inhibitors p16, p21, and p27 in HepG2 cells but not in HuH6, Caco2, or MCF7 cells. Treatment with 1,4-diamino-2,3-dicyano-1,4-bis(methylthio)butadiene (U0126) (an extracellular signal-regulated kinase inhibitor) ...
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