drug therapy is a complex and important process and because of the importance of drug interactions, especially in in-patients, accompanying problems and obstacles would exist as a result of concomitant use of drugs in these patients. for this purpose 3130 prescription order forms from bou-ali hospital were collected and all potential drug interactions presentwere extracted and evaluated in term...

The COVID-19 pandemic sparked the development of novel anti-viral drugs that have shown to be effective in reducing both fatality and hospitalization rates patients with elevated risk for related morbidity or mortality. Currently, nirmatrelvir/ritonavir (Paxlovid™) fixed-dose combination is recommended by World Health Organization treatment COVID-19. ritonavir component an inhibitor cytochrome ...

Drug-drug interaction and herb-drug interaction have been frequently reported when patients take propofol in combination with other important clinical drugs or herbs. Intestinal bacteria-catalyzed biotransformation process might significantly change the properties of compounds, such as the efficiency, toxicity, and the pharmacokinetic behaviours. The present study aims to investigate whether th...

Chelidonium majus L. (Papaveraceae) is a medicinal herb used in various traditional systems of medicine to treat ulcer, cancer, oral infection, liver disorders, chronic bronchitis, asthma, etc. Different parts of this plant contain numerous therapeutically important alkaloidal constituents such as chelidonine, chelerythrine, sanguinarine, berberine and so on. The plant and its active compounds ...

Background. Carbamazepine (CBZ) is a first-line antiepileptic drug which may be prone to drug interactions. Systematic review of herb- and food-drug interactions on CBZ is warranted to provide guidance for medical professionals when prescribing CBZ. Method. A systematic review was conducted on six English databases and four Chinese databases. Results. 196 out of 3179 articles fulfilled inclusio...

abstract: warfarin is the most commonly used oral anticoagulant drug in clinical practice with extreme inter and intra-individual variation in pharmacokinetic properties. na valproate, a broad spectrum anticonvulsant agent, is best known for its enzyme inhibition properties and also displacement of protein binding sites. interaction between warfarin and psychotropic drugs including valproate ar...

Based on more than 20 years’ clinical experience of integrative medicine in both China and America, using a series of experiential cases mainly of herbs/TCM intervention on kidney diseases and enhancing well-being, and from the perspective as a nephrologist, this paper presents the basic modalities of integrative medicine (IM) by describing the clinical skill of knowing how and when to use herb...

The types of pharmaceutical products include cosmetics and drugs. Some the comprise a mix drugs herbs without considering their interaction effects. Drug-herb interactions (DHIs) refer to between conventional herb medicines. However, available information on DHIs are scattered because it has heterogeneous databases website resources, apart from some paid or subscribed databases. Easy access wou...