Background and Objectives: Hereditary nonpolyposis colorectal cancer (HNPCC) is an autosomal dominant cancer predisposition syndrome caused by germ-line mutations in DNA mismatch repair genes. Tumors arising as a result of these mutations display instability in a sequence area known as microsatellites. Studies have shown that some Bethesda markers (BAT25, BAT26) are more efficient than other...

Notations and conventions 296 Introduction 296 I. Serre duality and almost split sequences 300 I.1. Preliminaries on Serre duality 300 I.2. Connection between Serre duality and Auslander–Reiten triangles 304 I.3. Serre functors on hereditary abelian categories 307 II. Hereditary noetherian abelian categories with non-zero projective objects 309 II.1. Hereditary abelian categories constructed fr...

Hereditary endocrine diseases are an important group of diseases with great heterogeneity. The current classification for hereditary endocrine disease is mostly based upon anatomy, which is helpful for pathophysiological interpretation, but does not address the pathogenic variability associated with different underlying genetic causes. Identification of an endocrinopathy-associated genetic alte...

Background Gastrointestinal (GI) complications such as constipation, diarrhea and gastroparesis are common in hereditary transthyretin (ATTR) amyloidosis. The mechanisms behind these disturbances have not been fully elucidated and the patients’ small bowel function remains largely unexplored. The aim of the present study was to compare the small bowel motility in patients with hereditary ATTR a...