81 Topical cyclosporine as an alternative treatment for herpetic interstitial keratitis Ciclosporina tópica como alternativa eficaz en el tratamiento de las queratitis intersticiales herpéticas Dear Sir, Infection due to herpes simplex virus (HSV), also known as human herpes virus (HHV), continues to be the most frequent cause of corneal blindness in developed countries, where the prevalence ra...

Both viral and host genetics affect the outcome of herpes simplex virus type 1 (HSV-1) infection in humans and experimental models. Little is known about specific host gene variants and molecular networks that influence herpetic disease progression, severity, and episodic reactivation. To identify such host gene variants we have initiated a forward genetic analysis using the expanded family of ...

A 33-year-old man developed Herpesvirus hominis type 2 (HVH-2) eye disease following a herpetic lesion of the penis. The sequence of ocular involvement suggested that the virus had been transmitted endogenously from the genital lesion: granulomatous iritis was followed by interstitial keratitis and then by dendritic keratitis. Recurrent bacterial ulcers ultimately required a conjunctival flap. ...

Florenal, a new antiviral preparation, has shown inhibitory action on the cytopathic effect of herpesvirus in tissue culture. Florenal had a marked therapeutic effect in mice challenged intracerebrally with the herpesvirus. Clinical evaluation of herpetic keratitis, adenovirus conjunctivitis, and epidemic keratoconjunctivitis patients treated with Florenal ophthalmic ointment revealed a good th...

Blood and tear levels of immunoglobulins against herpes simplex virus (HSV) were examined in 28 patients with dendritic keratitis over a period of 28 days. By means of an indirect micro-immunofluorescent technique blood and tear HSV IgG were detected, but neither circulating HSV IgM nor local HSV IgA were found. Over a four-week interval non-diagnostic fluctuations of HSV IgG occurred in most p...

%$%%protective effect of glycoprotein D (gD) immunization against murine herpetic keratitis was investigated. gD was purified by affinity chromatography using anti-gD monoclonal antibodies. Prior immunization with gD was shown to be effective in protecting mice from both the development of stromal keratitis and the spread of the virus to the central nervous system. The level of serum antibodies...

This report analyzes the role of vascular endothelial growth factor (VEGF)-induced angiogenesis in the immunoinflammatory lesion stromal keratitis induced by ocular infection with herpes simplex virus (HSV). Our results show that infection with replication-competent, but not mutant, viruses results in the expression of VEGF mRNA and protein in the cornea. This a rapid event, with VEGF mRNA dete...

PURPOSE The purpose of this study is to describe the diagnosis, course, and outcome of a case of Acanthamoeba and Stenotrophomonas keratitis with a fungal keratitis in the contralateral eye. METHODS A case of Acanthamoeba and Stenotrophomonas keratitis was diagnosed with confocal microscopy and cultures with confocal diagnosis of fungal keratitis in the fellow eye. RESULTS During the initia...

PURPOSE To report the outcomes of laser in situ keratomileusis (LASIK) in patients with a history of ocular herpes simplex virus (HSV) or herpes zoster ophthalmicus (HZO). SETTING Clínica Baviera, Instituto Oftalmológico Europeo, Madrid, Spain. METHODS In this retrospective case series, the records of eyes with a history of ocular herpes that had LASIK from 2003 through 2005 were reviewed. ...