BACKGROUND Herbal therapies are potential alternatives and adjuncts for depression treatment. The present study aims to investigate the antidepressant-like effects of hydroalcoholic Hemerocallis citrina extracts and its potential neuropharmacological components. METHODS Hydroalcoholic H. citrina extracts were phytochemically analyzed. Behavioral models, including tail suspension tests and ope...

The present study was to evaluate the protective role of hesperidin (HDN) against iron-induced hepatic and renal toxicity in rats. Administration of iron (30 mg/kg body weight) intraperitoneally for 10 days, the levels of serum hepatic markers, renal functional markers, lipid profile, lipid peroxidation markers and iron concentration in blood were significantly (p < 0.05) increased. The toxic e...

Flavonoids are well known as a large class of polyphenolic compounds, which have a variety of physiological activities, including anti-influenza virus activity. The influenza A/WSN/33 infected A549 cells have been used to screen anti-influenza virus drugs from natural flavonoid compounds library. Unexpectedly, some flavonoid compounds significantly inhibited virus replication, while the others ...

Significant levels of flavonoids with antioxidant properties can be found in citrus species. Flavonoids are a class plant chemical known for wide range pharmacological activities. Notable among these is Hesperidin. It has quite number biological properties, like anti-inflammatory and properties. Numerous studies have examined the impacts hesperidin its underlying mechanisms throughout last few ...

In a previous communication (1) it was reported that certain vitamin I’ compounds exerted an inhibitory action on the breakdown of hyaluronic acid by testis hyaluronidase, as determined turbidimetrically. This action was manifested for the most part only when the compounds in question were combined with ascorbic acid, and only when their concentration was relatively high (0.1 mg. per cc.). Sinc...

Rotenone a widely used pesticide that inhibits mitochondrial complex I has been used to investigate the pathobiology of PD both in vitro and in vivo. Studies have shown that the neurotoxicity of rotenone may be related to its ability to generate reactive oxygen species (ROS), leading to neuronal apoptosis. The current study was carried out to investigate the neuroprotective effects of hesperidi...

Polyphenolic compounds such as eriocitrin, luteolin-7-O-rutinoside, diosmin, hesperidin, narirutin, isorhoifolin, rosmarinic and caffeic acids were identified in an aqueous extract (Ex) obtained from peppermint leaves (Menthae x piperitae folium). The content of polyphenols in Ex was as follows: eriocitrin 38%, luteolin-7-O-rutinoside 3.5%, hesperidin 2.9%, diosmin 0.8%, isorhoifolin 0.6%, nari...

Diosmin and hesperidin are natural flavonoid glycosides found in various plant materials, mainly in citrus fruits in different concentrations. Diosmin for pharmaceutical use is obtained mainly semi-synthetically from hesperidin. Hesperidin often accompanies diosmin as a natural impurity in different pharmaceutical formulations; therefore, a simple, fast and precise method for the simultaneous a...

Background: Hesperidin is a bioflavonoid glycoside mainly found in citrus fruit and has been shown radio-protective potential in various measurement systems. Objective: In this article aims to investigate the radio-protective effect of hesperidin on the liver of Sprague Dawely rats. Material and Methods: In this clinical study, 40 male rats were selected randomly and divided into 8 ...

BACKGROUND Epidemiologic data suggest inverse associations between citrus flavanone intake and cardiovascular disease (CVD) risk. However, insufficient randomized controlled trial data limit our understanding of the mechanisms by which flavanones and their metabolites potentially reduce cardiovascular risk factors. OBJECTIVE We examined the effects of orange juice or a dose-matched hesperidin...