Hailey±Hailey disease (HHD) is an autosomal dominant chronic blistering disease, which is histologically characterized by keratinocyte acantholysis and epidermal cleft formation (Burge, 1992). The disease typically presents in middle age as crusted erosions or circinate plaques in sites exposed to friction such as the neck, axillae, groin, and perineum. Recently, the gene ATP2C1 has been identi...

BACKGROUND Little is known about patients' and carers' experiences of interacting with home haemodialysis (HHD) technology, in terms of user experience, how the design of the technology supports safety and fits with home use, and how the broader context of service provision impacts on patients' use of the technology. METHODS Data were gathered through ethnographic observations and interviews ...

BACKGROUND Hailey-Hailey disease (HHD), or benign familial pemphigus, is a rare autosomal dominant genodermatosis characterized by the formation of blisters. Eruptions are usually located in large skin folds, and when blisters become infected the condition can be very painful and disabling. HHD is difficult to treat. Many topical and systemic treatments have been used to bring exacerbations und...

To investigate the ventricular expression of atrial natriuretic peptide (ANP) in human hypertrophic hearts, we conducted an immunohistochemical study of 130 endomyocardial biopsy specimens obtained from the right side of the ventricular septum (RVB), left ventricular free wall (LVB), or both from a total of 80 patients: 44 patients with hypertrophic cardiomyopathy (HCM), 14 with apical hypertro...

To investigate the ventricular expression of atrial natriuretic peptide (ANP) in human hypertrophic hearts, we conducted an immunohistochemical study of 130 endomyocardial biopsy specimens obtained from the right side of the ventricular septum (RVB), left ventricular free wall (LVB), or both from a total of 80 patients: 44 patients with hypertrophic cardiomyopathy (HCM), 14 with apical hypertro...

In a graph G=(V; E), the eccentricity e(v) of a vertex v is max{d(v; u): u∈V}. The center of a graph is the set of vertices with minimum eccentricity. A house–hole–domino-free (HHD-free) graph is a graph which does not contain the house, the domino, and holes (cycles of length at least 2ve) as induced subgraphs. We present an algorithm which 2nds a central vertex of a HHD-free graph in O( 1:376...

The RDPLF collects the main peritoneal dialysis data from centers in French-speaking countires and, since 2012, home hemodialysis (HHD) data. This article presents a summary of results 2020. It highlights important differences practices and patient profiles between countries. Mortality patients with clinical symptoms COVID-19 varied 15 to 63% depending on country. A slight drop incidence rate f...

The integrated use of dialysis modalities alongside transplantation over a lifetime of renal replacement is often necessary and well established. In general, outcomes are more favourable when using home-based treatments, but what is less certain is the value of using these modalities sequentially. To explore this, using data from the Australian and New Zealand Dialysis and Transplantation (ANZD...

AIMS We evaluated the relationship between the mitral inflow velocities by pulsed Doppler echocardiography and mitral annular motion velocities by pulsed Doppler tissue imaging in patients with mitral annular calcification. METHODS AND RESULTS Fifty-three patients with mitral annular calcification were divided into two groups: severe mitral annular calcification (n=15, mitral annular calcific...

Hypertension is highly prevalent1-3 and it is the cause of numerous complications, the most common and important of which are of cardiac origin.3-5 In spite of this, no practical classification of hypertensive heart disease (HHD) is available. We present a new trichotomous classification of HHD, similar to the tumor, node, and metastasis (TNM) classification used for cancer. Hypertension causes...