The ultrastructure of the ocular pigment abnormality of human Chédiak-Higashi syndrome is described. The presence of giant abnormal melanosomes, probably the end result of the fusion of smaller abnormal organelles, was the most striking pathologic finding. This defect involved both optic cup and neural crest-derived melanocytes; the former were affected more severely. Giant lysosome-like organe...

Angela-Guiovana Rincón, Elizabeth León, Rodrigo Jiménez, Sandra Parra, Carlos-Andrés Peña y Cesar Pulgarín 1 Laboratory for Environmental Biotechnology, Institute of Environmental Engineering 2 Ecosystem Management Laboratory, Institute of Environmental Engineering 3 Air Pollution Laboratory (LPAS) 4 Logic systems Laboratory (LSL) Swiss Federal Institute of Technology, CHB Ecublens CH 1015 Laus...

1 Departamento de Microbiologı́a I, Inmunologı́a, Facultad de Medicina, Universidad Complutense, 28040 Madrid, Spain 2 Inmunotek SL, Alcalá de Henares, 28805 Madrid, Spain 3 School of Life and Health Sciences, Aston University, Birmingham B4 7ET, UK 4ATR, LLC, Worcester, MA 01606, USA 5Department of Mycobacteriology, National Institute of Infectious Diseases, Higashi-Murayama, Tokyo 189-0002, Japan

Recent ERP findings challenge the widespread assumption that syntactic and semantic processes are tightly coupled. Syntactically well-formed sentences that are semantically anomalous due to thematic mismatches elicit a P600, the component standardly associated with syntactic anomaly. This 'thematic P600' effect has been attributed to detection of semantically plausible thematic relations that c...

Graduate School of Integrated Arts and Sciences, Hiroshima University, Higashi-Hiroshima, Hiroshima 739-8521 Frontier Research System, The Institute of Physical and Chemical Research (RIKEN), Wako, Saitama 351-0198 AdSM, Hiroshima University, Higashi-Hiroshima, Hiroshima 739-8530 Center for Theoretical Physics, Physics Department, CSCS, The University of Michigan, Ann Arbor, MI 48109-1040, U.S....