OBJECTIVE To determine the feasibility of using either fasting plasma glucose or HbA(1c) to identify individuals in the U.S. population who meet the Diabetes Prevention Program (DPP) criteria for intervention, defined as BMI >/=24 kg/m(2), fasting plasma glucose level 96-125 mg/dl, and 2-h glucose level 140-199 mg/dl in an oral glucose tolerance test (OGTT). RESEARCH DESIGN AND METHODS Analys...

OBJECTIVE To evaluate whether measuring fasting plasma glucose concentration is an easier screening procedure for gestational diabetes mellitus than the 1 hour 50 g glucose challenge test. DESIGN Prospective population based study. SETTING Outpatient clinic in a university hospital. PARTICIPANTS 520 pregnant women (328 (63%) white, 99 (19%) Asian, 31 (6%) African, 62 (12%) others) with me...

1. Danazol elevates plasma insulin, plasma glucagon and serum low-density lipoprotein concentrations and reduces the serum high-density lipoprotein concentration. 2. Associations between these disturbances were studied in 17 women receiving danazol therapy for endometriosis. Eleven women underwent intravenous glucose tolerance tests with measurement of plasma glucose, insulin, C-peptide and glu...

While fasting has been practiced for centuries, its beneficial effects was unknown until recently. This review tries to analyze the current literature of how fasting and intermittent fasting (IF) could affect clinical pathological parameters, learning, mood and brain plasticity. The effects of different ways of fasting on metabolism and stress were also explored. Animal experiments have elucida...

background: in 2-4% of couples in fertile ages, recurrent pregnancy loss (rpl) occurs which consisted one out of 300 pregnancies. the aim of this study was to comparison insulin resistance (ir) in patients with rpl to normal individuals. materials and methods: in a case-controlled, prospective study, 49 non-pregnant, non-diabetic women with early rpl as the case group and 49 non-pregnant, non-d...

This study investigated the effects of high-fat diet on metabolic factors in the presence of acute foot-shock and psychological stresses in male Wistar rats. The animals were divided into high-fat (45 % cow intra-abdominal fat) and normal (standard pellets) diet groups; then, each group was allocated into stressed and control groups. Stress was induced by a communication box. Blood samples were...

OBJECTIVE Our objective was to examine the mechanisms via which exenatide attenuates postprandial hyperglycemia in type 2 diabetes mellitus (T2DM). STUDY DESIGN Seventeen T2DM patients (44 yr; seven females, 10 males; body mass index = 33.6 kg/m(2); glycosylated hemoglobin = 7.9%) received a mixed meal followed for 6 h with double-tracer technique ([1-(14)C]glucose orally; [3-(3)H]glucose i.v...

Impaired fasting glucose (fasting plasma glucose 6.1 to 6.9 mmol/L [110 to 125 mg/dL]) is a common glycemic disorder which usually progress to diabetes mellitus. The relationships between impaired fasting glucose, other risk factors including blood pressure, and mortality have never been clearly investigated. We studied 63 443 consecutive men (ages 21 to 60 years), each of whom had a routine he...

BACKGROUND Carotid intima-media thickness (C-IMT) is a reliable predictor of cardiovascular events. We Investigated the relationship between markers of glycemia and C-IMT in intermediate-risk cardiovascular patients. METHODS This study analyzed 427 subjects, aged 35 to 74 years (mean, 60.3 ± 8.5 years), 55 % women, enrolled into the MARK study. Including 231 subjects defined as normal glucose...