Hyperglycemia may contribute directly to pericyte loss and capillary leakage in early diabetic retinopathy. To elucidate relative contributions of glycation, glycoxidation, sugar autoxidation, osmotic stress and metabolic effects in glucose-mediated capillary damage, we tested the effects of D-glucose, L-glucose, mannitol and the potentially protective effects of aminoguanidine on cultured bovi...

introduction: in some intoxicated patients, cerebrospinal fluid (csf) is examined due to the prolonged loss of consciousness, focal neurologic findings, and fever of unknown origin. we aimed to evaluate the probable relationship between the different toxicity causes and the csf indices in poisoned patients and determine if they could predict the patients’ outcome. methods: all patients who had ...

Epidemiological evidence suggests a reduction in the incidence of coronary heart disease, cancer and osteoporosis in populations with a high dietary intake of plant estrogen or phytoestrogen. The clinical benefit of phytoestrogens in cereals, vegetables and medicinal plants is attracting increasing attention for the general public. In the present study, we examined the effect of phytoestrogenic...

Berberine, an isoquinoline alkaloid found in some traditional medicinal plants, such as Berberis vulgaris and Coptis Chinensis , has been considered effective drug treating obesity, hypertension, type-2 diabetes, hyperlipidemia, gout humans animals. It currently certain applications fish nutrition health, mainly because it strong biological pharmacological properties, antioxidative, anti-inflam...

It has recently been shown that an increase in the cellular chelatable iron pool is sufficient to cause cell damage. To further characterize this kind of injury, we artificially enhanced the chelatable iron pool in L929 mouse fibroblasts using the highly membrane-permeable complex Fe(III)/8-hydroxyquinoline. This iron complex induced a significant oxygen-dependent loss of viability during an in...

background: data shows vanadium protects pancreatic beta cells (bc) from diabetic animals. whether this effect is direct or through the relief of glucose toxicity is not clear. this study evaluated the potential effect of oral vanadyl sulfate (vanadium) on glycemic status and pancreatic bc of normal and diabetic rats. methods: rats were divided into five groups of normal and diabetic. diabetes ...

Patients requiring prolonged intensive care are at high risk for multiple organ failure and death. Insulin resistance and hyperglycemia accompany critical illness, and the severity of this “diabetes of stress” reflects the risk of death. Recently it was shown that preventing hyperglycemia with insulin substantially improves outcome of critical illness. This article examines some potential mecha...

Glucose is the main energy substrate for the brain. There is now extensive evidence indicating that the metabolic profile of neural cells with regard to glucose utilization and glycolysis rate is not homogenous, with a marked propensity for glycolytic glucose processing in astrocytes compared to neurons. Methylglyoxal, a highly reactive dicarbonyl compound, is inevitably formed as a by-product ...

Patients requiring prolonged intensive care are at high risk for multiple organ failure and death. Insulin resistance and hyperglycemia accompany critical illness, and the severity of this "diabetes of stress" reflects the risk of death. Recently it was shown that preventing hyperglycemia with insulin substantially improves outcome of critical illness. This article examines some potential mecha...

In the current study, we used muscle-specific TRIB3 overexpressing (MOE) and knockout (MKO) mice to determine whether TRIB3 mediates glucose-induced insulin resistance in diabetes and whether alterations in TRIB3 expression as a function of nutrient availability have a regulatory role in metabolism. In streptozotocin diabetic mice, TRIB3 MOE exacerbated, whereas MKO prevented, glucose-induced i...