The cellular basis of the genetic control of the immune response to poly(LTyr, LGlu)-polyDLAla--polyLLys [(T,G)-A--L] in SJL (H-2s, low responder) mice has been investigated using T-cell factors. Thymocytes of SJL origin were educated to (T,G)-A--L and tested for their ability to produce an antigen-specific factor capable of cooperating in vivo with bone marrow cells of either SJL or C3H.SW (hi...

previous studies had shown that sub-inhibitory concentrations of silver sulphadiazine (agsd) stimulated the production of toxic shock syndrome toxin-1 in certain strains (responder strains) of staphylococcus aureus and that protease production was also affected. no changes were detected in other strains (non-responders). extracellular proteins from eleven responder and non-responder strains gro...

Long-term-cultured poly(Tyr, Glu)-poly-D,L,-Ala-poly-Lys [(T,G)-A--L]-reactive T cells and clones derived from (high responder x low responder)F1 [(C57BL/6 x A/J)F1] mice were shown to recognize (T,G)-A--L presented by cells from low responder strain A/J mice. The antigen-presenting determinant(s) that allowed recognition of (T,G)-A--L by such T cell clones was controlled by the I-A subregion o...

Background and Aims: Cytomegalovirus (CMV) has worldwide distribution, and its prevalence rate depends on factors such as economic and geographical conditions. An important way of the virus transmission is via blood. Due to high prevalence of anti-CMV antibodies in blood donors and lack of data concerning its seroprevalence in the region, this study was carried out to determine the prevalence r...

Innate immune cells, including myeloid cells — derived suppressor (MDSCs) are supposed to play an important role in the pathogenesis of axial spondyloarthritis (AxSp). Myeloid represent a heterogeneous population immature capable suppressing innate and adaptive responses with most pronounced activity against T cells. Biological disease-modifying antirheumatic drugs (bDMARDs) can reduce clinical...

Certain monoclonal antibodies (MoAbs) specific for platelet membrane glycoproteins are known t o be capable of activating platelets, and it is generally thought that platelets from normal subjects are equally susceptible t o stimulation by such MoAbs. We found that platelets from 20 normal donors varied significantly in their sensitivity to three lgGl murine MoAbs specific for membrane glycopro...

SUMMARY In this issue of Cancer Discovery, AI-Ahmadie and colleagues identify a somatic mutation in the RAD50 gene as a likely contributing factor to an unusual curative response to systemic combination therapy employing the DNA-damaging agent irinotecan and a checkpoint kinase 1 inhibitor in a patient with recurrent, metastatic small-cell cancer. This study highlights the importance of in-dept...

Introduction: Blood derived products have been known as an effective treatment for many years. However, this treatment is not without risk of infections transmission including hepatitis B virus (HBV) and hepatitis C virus (HCV) and human immune-deficiency virus (HIV) in people who received the blood. Nevertheless, due to a high risk of blood born diseases through blood transfusion, screening ...