A topical o/w cream containing tretinoin microspheres was prepared. Gelatin microspheres of tretinoin were prepared using coacervation method. These microspheres contained about 50% w/w tretinoin. The particle size range of microspheres was between 90-150 m m. In vitro drug release from microspheres and a cream formulation was studied. It was shown that drug release from microspheres followed H...

Abstract Kristiansen and Murwanashyaka recently proved that Robinson arithmetic, Q, is interpretable in an elementary theory of full binary trees, T. We prove that, conversely, T Q by producing a formal interpretation concatenation QT + , thereby also establishing mutual interpretability with several well-known weak essentially undecidable theories numbers, strings, sets. introduce “hybrid” str...

A sustained-release tablet formulation should ideally have a proper release profile insensitive to moderate changes in tablet hardness that is usually encountered in manufacturing. In this study, matrix aspirin (acetylsalicylic acid) tablets with ethylcellulose (EC), Eudragit RS100 (RS), and Eudragit S100 (S) were prepared by direct compression. The release behaviors were then studied in two co...

In this study, buccal mucoadhesive tablets of meloxicam were formulated for drug delivery as an alternative route. Direct compression method was applied for the preparation of tablets. Also, different polymers, including hydroxypropyl methyl cellulose (HPMC) 1000, 4000, and 10000, as well as carbopol 934p and carbopol 971p were used as the mucoadhesive polymer and retardant polymer. Thirteen fo...

1. Imagawa S, Yamaguchi Y, Higuchi M, et al. Levels of vascular endothelial growth factor are elevated in patients with obstructive sleep apnea-hypopnea syndrome. Blood. 2001;98:1255-1257. 2. Eckardt K-U, Boutellier U, Kurtz A, Schopen M, Koller EA, Bauer C. Rate of erythropoietin formation in humans in response to acute hypobaric hypoxia. J Appl Physiol. 1989;66:1785-1788. 3. Guilleminault C, ...

Jun Maeda,1 Bin Ji,1 Toshiaki Irie,1 Takami Tomiyama,2 Masahiro Maruyama,1 Takashi Okauchi,1 Matthias Staufenbiel,3 Nobuhisa Iwata,4 Maiko Ono,1 Takaomi C. Saido,4 Kazutoshi Suzuki,1 Hiroshi Mori,2 Makoto Higuchi,1 and Tetsuya Suhara1 1Molecular Imaging Center, National Institute of Radiological Sciences, Chiba, Chiba 263-8555, Japan, 2Department of Neuroscience, Osaka City University Graduate ...