2,3,7,8-tetrachlorodibenzo-p-dioxin (tcdd) is a by-product o f t he trichlorophenol (herbicide) production and is also produced through a variety of combustion processes. it appears that tcdd is a ubiquitous chemical, particularly in industrialised countries, and the liver is the target organ of its toxicity. the prominent hepatotoxic effect of tcdd is progressive centrilobular necrosis. the is...

BACKGROUND The association between circulating microRNA-122 (miR-122) and histopathological features of nonalcoholic fatty liver disease (NAFLD) remains unclear. METHODS The association of serum miR-122 levels with histopathological features of NAFLD (steatosis, ballooning, lobular inflammation, and stage, as histological components of nonalcoholic steatohepatitis) was examined in serial live...

background & objectives: oral submucous fibrosis (osmf) is a condition where excessive deposition of dense collagen fibers occurred in the connective tissue of oral mucosa. an alteration of collagen necessitates an in depth understanding of collagen in oral tissues as no breakthrough studies have been reported. therefore the aim was to correlate the clinical, functional and histopathologica...

to investigate the cardioprotective potential of the aqueous extract of allium cepa linn. bulb in isoprenaline-induced myocardial injury in wistar albino rats. in vitro total phenolic, total flavonoid content and 2, 2’-diphenyl-1-picrylhydrazyl hydrate radical scavenging activity was measured. isoprenaline-induced myocardial injury model was used to evaluate in vivo effect of aqueous extract of...

BACKGROUND Although the correlation between metabolic abnormality and gastric cancer has been extensively investigated, the question of whether metabolic parameters might influence the efficacy of chemotherapy in locally advanced gastric cancer is still unanswered. In our present study, we investigated the relationship between serum fasting glucose, lipid levels, and histopathological response ...

To study clinical and histopathological changes occur within the first 12 hours of strangulating obstruction of the small intestine in equine, twenty five adult donkeys were used in an experimental study. Strangulation obstruction of the small intestine was performed for 3, 6, 9 and 12 hours, respectively. Clinical examination was done before surgery and at 3 hours intervals postoperatively. Af...

BACKGROUND The aim of this study was to investigate the distribution of different types of primary orbital tumors, histopathological diagnosis, and postoperative complications. MATERIAL AND METHODS We analyzed 122 patients (68 women and 54 men) with orbital tumors, hospitalized in the ENT Department of the Medical University of Silesia in Katowice during 1990-2013. The patients were character...

Copyright  2014 irjpbs The aim of this work is to study the hepatoprotective effect of polyherbal formulations contains some Indian medicinal plant. The three different herbal formulations obtained from different medicinal plant extracts were evaluated for hepatoprotective in rats by induced liver damage by paracetamol. Paracetamol (3g/kg, p.o) was administered a single dose to induce hepatoto...