BACKGROUND Initial investigations demonstrated a deficiency of glutathione (GSH) in the epithelial lining fluid (ELF) of HIV-seropositive patients. In a recent study, our laboratory was unable to document such a deficiency. The current study was performed in an attempt to reconcile those disparate findings. STUDY OBJECTIVES To determine if ELF GSH decreases over time in asymptomatic HIV-serop...

Abstract Background We conducted a real-life study of health-related quality life (HRQoL) transformation before and 12 weeks after sofosbuvir daclatasvir therapy in HCV/HIV co-infected patients. Factors related to the significant changes each HRQoL domain/item were also evaluated. Methods A prospective was performed HIV integrated clinic at Cipto Mangunkusumo Hospital, Jakarta. patients who sta...

Objective: Substance use is a gradually increasing public health problem. Viruses such as hepatitis B, C, and HIV can be transmitted with intravenous substance cause significant morbidity mortality. Therefore, we aimed to evaluate the HIV, syphilis test results of patients followed at Şanlıurfa Alcohol Drug Addiction Research Treatment Training Center (AMATEM) clinic. Methods: The age, gender, ...

BACKGROUND Previously, we demonstrated that measles antibody prevalence was lower at age 12 months among children infected with human immunodeficiency virus (HIV) than uninfected children following measles vaccination (MV) at ages 6 and 9 months. Among HIV-uninfected children, measles antibody prevalence was lower among 1- than 2-dose MV recipients. Here, we report results through age 24 months...

BACKGROUND Genital viral load (GVL) is the main determinant of sexual transmission of human immune-deficiency virus (HIV). The effect of antiretroviral therapy (ART) on local cervico-vaginal immunological factors associated with GVL is poorly described. We aimed to identify the risk factors of detectable GVL, and the impact of ART on HIV genital shedding and its correlates in a cohort of HIV-in...

BACKGROUND Eliminating mother-to-child transmission of HIV (EMTCT), defined as ≤50 infant HIV infections per 100 000 live births, is a global priority. Since 2011 policies to prevent mother-to-child transmission of HIV (PMTCT) shifted from maternal antiretroviral (ARV) treatment or prophylaxis contingent on CD4 cell count to lifelong maternal ARV treatment (cART). We sought to measure progress ...

Việc tuân thủ điều trị ARV (ART) có vai trò quyết định thành bại trong bệnh nhi nhiễm HIV/AIDS. Trẻ em HIV chủ yếu là những người tiếp nhận thụ động, việc ở trẻ vẫn còn một vấn đề thách thức Việt Nam. Mục tiêu: Đánh giá tỷ lệ HIV/ AIDS tại viện Nhi trung ương năm 2020 - 2021. Đối tượng và phương pháp nghiên cứu: Nghiên cứu mô tả cắt ngang tiến hành trên 257 Bệnh đang phòng khám ngoại trú chăm s...

BACKGROUND Acyclovir (ACV), a highly specific anti-herpetic drug, acts as a DNA chain terminator for several human herpesviruses (HHVs), including HHV-2 (HSV-2), a common human immunodeficiency virus (HIV)-1 co-pathogen. Several trials demonstrated that HSV-2 suppressive therapy using ACV or its prodrug valacyclovir (valACV) reduced plasma HIV-1 viral load (VL) in HIV-1/HSV-2 coinfected persons...

Dual method use, use of condoms plus another effective contraceptive method, is important in settings with high rates of unintended pregnancy and HIV infection. We evaluated the association of HIV status with dual method use in a cohort of postpartum women. Women completed baseline surveys in the postpartum ward and telephone surveys about contraceptive use 3, 6, and 12 months later. Nonpregnan...

The pathogenesis of defective interleukin (IL)-12 and interferon (IFN)-gamma production in human immunodeficiency virus (HIV)-infected patients remains to be elucidated. This study investigated the possibility that perturbations in CD40 ligand signaling are involved in this defect. CD40 ligand trimer (CD40LT) stimulated peripheral blood mononuclear cell (PBMC) production of IL-12 in response to...