Three subpopulations of human myeloid progenitor cells (CFU-GM) can be distinguished by differences in their kinetics of development; the liquid phase pre-CFU-GM, the day 14 CFU-GM, and the day 7 CFU-GM. The relative cell membrane densities of the HLA-DR and HLA-DQ antigens expressed by the three subpopulations was investigated by comparing the amount of antibody required to deplete bone marrow...

As opposed to normal human skin where HLA-DR expression is restricted to the Langerhans cell (LC) population, HLA-DR, but not HLA-DS antigens can be readily detected on keratinocytes (KC) in certain disease states, i.e., cutaneous T cell lymphoma (CTCL), graft-vs-host disease (GVHD), and lichen planus (LP). To clarify the cellular origin of KC-bound HLA-DR antigens, we used a monoclonal antibod...

occur more frequently in persons who have inherited particular HLA antigens. Genes controlling the inheritance of the HLA antigens are located on chromosome 6, and the major histocompatibility complex (MHC) in man involves at least four gene loci (A, B, C and D) controlling at least 64 HLA specificities. Recently, certain genes have been identified which code for a group of HLA alloantigens dem...

successful clearance of hepatitis b virus (hbv) is a promising event in which host's immune system will attempt to get rid of the virus. the immunological events of hbsag seroclearance have attracted great attention in both natural history investigations and therapeutic trials. recent genome-wide association studies (gwas) has confirmed polymorphisms in the human leukocyte antigen (hla)-dp locu...

Aim: The aim of our survey was to identify spondyloarthritis – associated to HLA -B phenotypes in the population from north-eastern part of Romania. Genetic (HLA or nonHLA genes) and infectious factors are involved in determining spondyloarthritis susceptibility and severity. The most frequent association is with HLA-B27 antigen, but the extent of association of this antigen with spondyloarthri...

The influence of HLA mismatches between donor and recipient on the phenotypes, function, and specificity of T-lymphocyte cultures derived from endomyocardial biopsies was studied in 118 heart transplant recipients. In case of HLA-DR mismatches, the majority of the EMB-derived cultures were dominated by CD4+ T cells while, in patients with HLA-A and -B mismatches but without DR mismatches, CD8+ ...

BACKGROUND Celiac disease is an enteropathy characterized by gluten sensitivity and broad clinical aspect. Has a multifactorial cause and depends on genetic, immunological and environmental factors for its development. The genetic influence is given mostly by the human leukocyte antigens HLA DQ2 and DQ8. AIM To evaluate the prevalence of human leukocyte antigens DQ2 and DQ8 in three different...

Abstract Background and Aims The human leukocyte antigens (HLA) are the most diverse polymorphic genes in genome matching them is of vital importance for maximising survival kidney transplants. Maltese archipelago consists three inhabited islands Mediterranean Sea, with a total population just over half million people. HLA polymorphisms Malta have never been described. aim this study was to inv...

The US Food and Drug Administration approved intravenous immunoglobulin (IVIg), extracted from the plasma of thousands of blood donors, for removing HLA antibodies (Abs) in highly sensitized patients awaiting organ transplants. Since the blood of healthy individuals has HLA Abs, we tested different IVIg preparations for reactivity to HLA single antigen Luminex beads. All preparations showed hig...

Introduction: Recognition of human leukocyte antigens (HLA) is of importance for hematopoietic stem cell transplantation. Any HLA-mismatches between the donor and recipient can cause graft rejection or other complications. In HLA-typing experiments, usage of HLA-known reference cells accompany with HLA-unknown samples is obligatory. Some international centers represent these cells with high e...