Human recombinant erythropoietin is a synthetic hormone for treatment of some kinds of anemia. In this study, the effect of this hormone was investigated on blood cell changes in adult and immature rats. For this purpose, the hormone was administered at doses of 50, 100, and 200 IU/Kg (s.c.) twice a week for a period of 6 weeks. Then, the number of red blood cells (RBC), subtypes of white blood...

Background: Breast cancer (BC) is problem in developed and developing nations linked to a high mortality rate. Objective: In this study, we determined the relationships between osteopontin level, hormonal status, stage, BMI, age BC patients. Materials Methods: cross sectional 178 patients, ages ranged from 28 95 were randomly enrolled. Body mass index estimated. Plasma measured. Results: From t...

There are few options for treating hormone-refractory prostate cancer (PC). Various studies indicate that luteinizing hormone-releasing hormone (LHRH) agonists may have a direct inhibitory effect on prostate tumors mediated by specific LHRH receptors. One study evaluated LHRH receptors in hormone-dependent PC tissue, but no data have thus far been obtained on the presence of LHRH receptors in b...

Deficiency of vitamin D3 has become common in both developed and developing countries. Vitamin D receptors are found on the granulosa cells ovarian tissue its deficiency plays a role dysfunction. Anti Mullerian Hormone (AMH) is generated small growing follicles ovaries by cells. Serum AMH one marker for reserve. We reviewed current literature present clinical practice. There relationship betwee...

Gonadotropin-releasing hormone (GnRH) analogs (e.g., triptorelin) are developed to treat hormone-dependent reproductive cancers. However, these lack a significant direct antitumor activity make them suitable for hormone-refractory In this study, we examined different biological properties of lipid-modified GnRH analogs, with/without D-amino acid substitution at position 6 in prostate and ovaria...

Thyroid hormone, acting through thyroid hormone receptors is a key regulator of metabolic homeostasis. Repression of transcription is critical component of thyroid hormone signaling and is mediated through the association of corepressor proteins with thyroid hormone receptors. In this review we will discuss recent results elucidating multiple roles for corepressors in mediating thyroid hormones...