endometriosis is a gynecologic disorder characterized by the presence of viable, extrauterine endometrial tissue, predominantly on the ovary and pelvic peritoneum (1-3). typical symptoms consist of pelvic pain, dysmenorrhea, and infertility (1, 2). this condition takes place only in women of menstrual age, can grow or bleed cyclically and may cause adhesions (1, 2). endometriosis represents a w...

The mechanisms underlying deregulation of HOX gene expression in AML are poorly understood. The ParaHox gene CDX2 was shown to act as positive upstream regulator of several HOX genes. In this study, constitutive expression of Cdx2 caused perturbation of leukemogenic Hox genes such as Hoxa10 and Hoxb8 in murine hematopoietic progenitors. Deletion of the N-terminal domain of Cdx2 abrogated its ab...