BACKGROUND Insects have multiple hemocyte morphotypes with different functions as do vertebrates, however, their hematopoietic lineages are largely unexplored with the exception of Drosophila melanogaster. METHODOLOGY/PRINCIPAL FINDINGS To study the hematopoietic lineage of the silkworm, Bombyx mori, we investigated in vivo and in vitro differentiation of hemocyte precursors in the hematopoie...

There is still a good deal of confusion in the literature about how the use of a performance management system affects overall organizational performance. Some researchers find that performance management enhances both the financial and non-financial results of an organization, while others do not find any positive effects or, at most, ambiguous effects. An important step toward getting more cl...

In Drosophila and mammals, the canonical Hippo kinase cascade is mediated by Hpo/Mst acting through the intermediary kinase Wts/Lats to phosphorylate the transcriptional coactivator Yki/YAP/TAZ. Despite recent reports linking Yki/YAP/TAZ activity to the actin cytoskeleton, the underlying mechanisms are poorly understood and/or controversial. Using Drosophila imaginal discs as an in vivo model, ...

Two functional properties shared by many tumor suppressor genes are the inhibition of cell-cycle progression and the induction of apoptosis. Recent work in the fruit fly has uncovered a new pathway for cellular homeostasis, involving the scaffold protein Salvador (Sav) and the two protein kinases Hippo (Hpo) and Warts (Wts) [1–3]. All components of this pathway have mammalian homologs, of which...

Objective(s) The mechanism(s) by which antidepressants regulate the hypothalamic-pituitary-adrenal (HPA) axis remain elusive. The endocannabinoid system (eCBs) which exhibits antidepressant potential, appears to regulate the HPA axis activity. Therefore, we aimed to investigate the role of the eCBs in the action of doxepin including its effect on the HPA axis. Materials and Methods Male Wist...

Automated hyperparameter optimization (HPO) has gained great popularity and is an important component of most automated machine learning frameworks. However, the process designing HPO algorithms still unsystematic manual process: new are often built on top prior work, where limitations identified improvements proposed. Even though this approach guided by expert knowledge, it somewhat arbitrary....

Abstract Background Molecular autopsy represents an efficient tool to save the diagnosis in up one-third of sudden unexplained death (SUD). A defined gene panel is usually used for examination. Alternatively, it possible carry out a comprehensive genetic assessment (whole exome sequencing, WES), which also identifies rare, previously unknown variants. The disadvantage that dramatic number varia...

In this letter, we propose a model parameter identification method via hyperparameter optimization scheme (MI-HPO). Our adopts an efficient exploreexploit strategy to identify the parameters of dynamic models in data-driven manner. We utilize our for AV-21, full-scaled autonomous race vehicle. then incorporate optimized design modelbased planning and control systems platform. experiments, MI-HP...

Most machine learning algorithms are configured by a set of hyperparameters whose values must be carefully chosen and which often considerably impact performance. To avoid time-consuming irreproducible manual process trial-and-error to find well-performing hyperparameter configurations, various automatic optimization (HPO) methods—for example, based on resampling error estimation for supervised...

This paper describes a rendering pipeline for digital hologram synthesis. The pipeline is capable of handling triangle meshes, directional light sources, texture coordinates and advanced illumination models. Due to the huge computational requirements of hologram synthesis only the HPO holograms are considered.